SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α

Tumour vasculature influences drug delivery. Here, the authors show that SOD3 re-expression enhances doxorubicin delivery and effects through normalization of tumour vasculature via the HIF-2a/VE-cadherin pathway.

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Autores principales:	Emilia Mira, Lorena Carmona-Rodríguez, Beatriz Pérez-Villamil, Josefina Casas, María Jesús Fernández-Aceñero, Diego Martínez-Rey, Paula Martín-González, Ignacio Heras-Murillo, Mateo Paz-Cabezas, Manuel Tardáguila, Tim D. Oury, Silvia Martín-Puig, Rosa Ana Lacalle, Gemma Fabriás, Eduardo Díaz-Rubio, Santos Mañes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5a223591ab94254855b6f9c6cd6f2c6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:a5a223591ab94254855b6f9c6cd6f2c62021-12-02T17:33:04ZSOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α10.1038/s41467-018-03079-12041-1723https://doaj.org/article/a5a223591ab94254855b6f9c6cd6f2c62018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03079-1https://doaj.org/toc/2041-1723Tumour vasculature influences drug delivery. Here, the authors show that SOD3 re-expression enhances doxorubicin delivery and effects through normalization of tumour vasculature via the HIF-2a/VE-cadherin pathway.Emilia MiraLorena Carmona-RodríguezBeatriz Pérez-VillamilJosefina CasasMaría Jesús Fernández-AceñeroDiego Martínez-ReyPaula Martín-GonzálezIgnacio Heras-MurilloMateo Paz-CabezasManuel TardáguilaTim D. OurySilvia Martín-PuigRosa Ana LacalleGemma FabriásEduardo Díaz-RubioSantos MañesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emilia Mira Lorena Carmona-Rodríguez Beatriz Pérez-Villamil Josefina Casas María Jesús Fernández-Aceñero Diego Martínez-Rey Paula Martín-González Ignacio Heras-Murillo Mateo Paz-Cabezas Manuel Tardáguila Tim D. Oury Silvia Martín-Puig Rosa Ana Lacalle Gemma Fabriás Eduardo Díaz-Rubio Santos Mañes SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α
description	Tumour vasculature influences drug delivery. Here, the authors show that SOD3 re-expression enhances doxorubicin delivery and effects through normalization of tumour vasculature via the HIF-2a/VE-cadherin pathway.
format	article
author	Emilia Mira Lorena Carmona-Rodríguez Beatriz Pérez-Villamil Josefina Casas María Jesús Fernández-Aceñero Diego Martínez-Rey Paula Martín-González Ignacio Heras-Murillo Mateo Paz-Cabezas Manuel Tardáguila Tim D. Oury Silvia Martín-Puig Rosa Ana Lacalle Gemma Fabriás Eduardo Díaz-Rubio Santos Mañes
author_facet	Emilia Mira Lorena Carmona-Rodríguez Beatriz Pérez-Villamil Josefina Casas María Jesús Fernández-Aceñero Diego Martínez-Rey Paula Martín-González Ignacio Heras-Murillo Mateo Paz-Cabezas Manuel Tardáguila Tim D. Oury Silvia Martín-Puig Rosa Ana Lacalle Gemma Fabriás Eduardo Díaz-Rubio Santos Mañes
author_sort	Emilia Mira
title	SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α
title_short	SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α
title_full	SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α
title_fullStr	SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α
title_full_unstemmed	SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α
title_sort	sod3 improves the tumor response to chemotherapy by stabilizing endothelial hif-2α
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a5a223591ab94254855b6f9c6cd6f2c6
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SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α

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