Determining the optimal pulse number for theta burst induced change in cortical excitability

Abstract Theta-burst stimulation (TBS) is a form of non-invasive neuromodulation which is delivered in an intermittent (iTBS) or continuous (cTBS) manner. Although 600 pulses is the most common dose, the goal of these experiments was to evaluate the effect of higher per-dose pulse numbers on cortica...

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Autores principales:	Daniel M. McCalley, Daniel H. Lench, Jade D. Doolittle, Julia P. Imperatore, Michaela Hoffman, Colleen A. Hanlon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a5a26df7fb9a482f9c2b890d2e3e4fa8
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spelling	oai:doaj.org-article:a5a26df7fb9a482f9c2b890d2e3e4fa82021-12-02T17:32:59ZDetermining the optimal pulse number for theta burst induced change in cortical excitability10.1038/s41598-021-87916-22045-2322https://doaj.org/article/a5a26df7fb9a482f9c2b890d2e3e4fa82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87916-2https://doaj.org/toc/2045-2322Abstract Theta-burst stimulation (TBS) is a form of non-invasive neuromodulation which is delivered in an intermittent (iTBS) or continuous (cTBS) manner. Although 600 pulses is the most common dose, the goal of these experiments was to evaluate the effect of higher per-dose pulse numbers on cortical excitability. Sixty individuals were recruited for 2 experiments. In Experiment 1, participants received 600, 1200, 1800, or sham (600) iTBS (4 visits, counterbalanced, left motor cortex, 80% active threshold). In Experiment 2, participants received 600, 1200, 1800, 3600, or sham (600) cTBS (5 visits, counterbalanced). Motor evoked potentials (MEP) were measured in 10-min increments for 60 min. For iTBS, there was a significant interaction between dose and time (F = 3.8296, p = 0.01), driven by iTBS (1200) which decreased excitability for up to 50 min (t = 3.1267, p = 0.001). For cTBS, there was no overall interaction between dose and time (F = 1.1513, p = 0.33). Relative to sham, cTBS (3600) increased excitability for up to 60 min (t = 2.0880, p = 0.04). There were no other significant effects of dose relative to sham in either experiment. Secondary analyses revealed high within and between subject variability. These results suggest that iTBS (1200) and cTBS (3600) are, respectively, the most effective doses for decreasing and increasing cortical excitability.Daniel M. McCalleyDaniel H. LenchJade D. DoolittleJulia P. ImperatoreMichaela HoffmanColleen A. HanlonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel M. McCalley Daniel H. Lench Jade D. Doolittle Julia P. Imperatore Michaela Hoffman Colleen A. Hanlon Determining the optimal pulse number for theta burst induced change in cortical excitability
description	Abstract Theta-burst stimulation (TBS) is a form of non-invasive neuromodulation which is delivered in an intermittent (iTBS) or continuous (cTBS) manner. Although 600 pulses is the most common dose, the goal of these experiments was to evaluate the effect of higher per-dose pulse numbers on cortical excitability. Sixty individuals were recruited for 2 experiments. In Experiment 1, participants received 600, 1200, 1800, or sham (600) iTBS (4 visits, counterbalanced, left motor cortex, 80% active threshold). In Experiment 2, participants received 600, 1200, 1800, 3600, or sham (600) cTBS (5 visits, counterbalanced). Motor evoked potentials (MEP) were measured in 10-min increments for 60 min. For iTBS, there was a significant interaction between dose and time (F = 3.8296, p = 0.01), driven by iTBS (1200) which decreased excitability for up to 50 min (t = 3.1267, p = 0.001). For cTBS, there was no overall interaction between dose and time (F = 1.1513, p = 0.33). Relative to sham, cTBS (3600) increased excitability for up to 60 min (t = 2.0880, p = 0.04). There were no other significant effects of dose relative to sham in either experiment. Secondary analyses revealed high within and between subject variability. These results suggest that iTBS (1200) and cTBS (3600) are, respectively, the most effective doses for decreasing and increasing cortical excitability.
format	article
author	Daniel M. McCalley Daniel H. Lench Jade D. Doolittle Julia P. Imperatore Michaela Hoffman Colleen A. Hanlon
author_facet	Daniel M. McCalley Daniel H. Lench Jade D. Doolittle Julia P. Imperatore Michaela Hoffman Colleen A. Hanlon
author_sort	Daniel M. McCalley
title	Determining the optimal pulse number for theta burst induced change in cortical excitability
title_short	Determining the optimal pulse number for theta burst induced change in cortical excitability
title_full	Determining the optimal pulse number for theta burst induced change in cortical excitability
title_fullStr	Determining the optimal pulse number for theta burst induced change in cortical excitability
title_full_unstemmed	Determining the optimal pulse number for theta burst induced change in cortical excitability
title_sort	determining the optimal pulse number for theta burst induced change in cortical excitability
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a5a26df7fb9a482f9c2b890d2e3e4fa8
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Determining the optimal pulse number for theta burst induced change in cortical excitability

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