Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

Exosomes are RNA-containing lipid vesicles with roles in inter-tissue crosstalk. Here the authors show that exosome release from brown adipocytes is increased upon thermogenic activation, both in vitro and in vivo, and demonstrate that serum levels of exosomal miR-92 reflect brown fat activity in hu...

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Autores principales: Yong Chen, Joschka J. Buyel, Mark J. W. Hanssen, Franziska Siegel, Ruping Pan, Jennifer Naumann, Michael Schell, Anouk van der Lans, Christian Schlein, Holger Froehlich, Joerg Heeren, Kirsi A. Virtanen, Wouter van Marken Lichtenbelt, Alexander Pfeifer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/a5a3002cb6614c3fa06055d50ee9c5fe
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Sumario:Exosomes are RNA-containing lipid vesicles with roles in inter-tissue crosstalk. Here the authors show that exosome release from brown adipocytes is increased upon thermogenic activation, both in vitro and in vivo, and demonstrate that serum levels of exosomal miR-92 reflect brown fat activity in humans.

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