Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant

Abstract There is an unmet need for new influenza vaccine strategies that compensate for impaired vaccine responses in elderly individuals. Here, we evaluated the effectiveness of a single-stranded RNA (ssRNA) as an adjuvant to enhance the efficacy of inactivated influenza vaccine (IIV) in mouse mod...

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Autores principales:	Yoo-Jin Bang, So-Hee Hong, Hyo-Jung Park, Hye Won Kwak, Yu-Sun Lee, Jae-Yong Kim, Hyeong-Jun Park, Seo-Hyeon Bae, Hye-Jung Kim, Yun-Hee Kim, Hae Li Ko, Sang-In Park, Hun Kim, Gyeongjoo Park, Man-Seong Park, Jun Chang, Jae-Hwan Nam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a5a57738d3804b2ea87a1b31eecaa317
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spelling	oai:doaj.org-article:a5a57738d3804b2ea87a1b31eecaa3172021-12-02T17:52:12ZEffective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant10.1038/s41598-021-91445-32045-2322https://doaj.org/article/a5a57738d3804b2ea87a1b31eecaa3172021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91445-3https://doaj.org/toc/2045-2322Abstract There is an unmet need for new influenza vaccine strategies that compensate for impaired vaccine responses in elderly individuals. Here, we evaluated the effectiveness of a single-stranded RNA (ssRNA) as an adjuvant to enhance the efficacy of inactivated influenza vaccine (IIV) in mouse models. Immunization with the ssRNA along with IIV reduced viral titers as well as pathological and inflammatory scores in the lungs after influenza challenge in aged mice. ssRNA induced balanced Th1/Th2 responses with an increase in IgA titers. Moreover, the ssRNA adjuvant markedly increased the frequency of influenza HA-specific T cells and IFN-γ production along with the expression of genes related to innate and adaptive immune systems that could overcome immunosenescence in aged mice. Our findings indicate that ssRNA is an efficient vaccine adjuvant that boosts cellular and humoral immunity in aged mice, demonstrating its potential as a novel adjuvant for currently available influenza virus vaccines for elderly individuals.Yoo-Jin BangSo-Hee HongHyo-Jung ParkHye Won KwakYu-Sun LeeJae-Yong KimHyeong-Jun ParkSeo-Hyeon BaeHye-Jung KimYun-Hee KimHae Li KoSang-In ParkHun KimGyeongjoo ParkMan-Seong ParkJun ChangJae-Hwan NamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoo-Jin Bang So-Hee Hong Hyo-Jung Park Hye Won Kwak Yu-Sun Lee Jae-Yong Kim Hyeong-Jun Park Seo-Hyeon Bae Hye-Jung Kim Yun-Hee Kim Hae Li Ko Sang-In Park Hun Kim Gyeongjoo Park Man-Seong Park Jun Chang Jae-Hwan Nam Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant
description	Abstract There is an unmet need for new influenza vaccine strategies that compensate for impaired vaccine responses in elderly individuals. Here, we evaluated the effectiveness of a single-stranded RNA (ssRNA) as an adjuvant to enhance the efficacy of inactivated influenza vaccine (IIV) in mouse models. Immunization with the ssRNA along with IIV reduced viral titers as well as pathological and inflammatory scores in the lungs after influenza challenge in aged mice. ssRNA induced balanced Th1/Th2 responses with an increase in IgA titers. Moreover, the ssRNA adjuvant markedly increased the frequency of influenza HA-specific T cells and IFN-γ production along with the expression of genes related to innate and adaptive immune systems that could overcome immunosenescence in aged mice. Our findings indicate that ssRNA is an efficient vaccine adjuvant that boosts cellular and humoral immunity in aged mice, demonstrating its potential as a novel adjuvant for currently available influenza virus vaccines for elderly individuals.
format	article
author	Yoo-Jin Bang So-Hee Hong Hyo-Jung Park Hye Won Kwak Yu-Sun Lee Jae-Yong Kim Hyeong-Jun Park Seo-Hyeon Bae Hye-Jung Kim Yun-Hee Kim Hae Li Ko Sang-In Park Hun Kim Gyeongjoo Park Man-Seong Park Jun Chang Jae-Hwan Nam
author_facet	Yoo-Jin Bang So-Hee Hong Hyo-Jung Park Hye Won Kwak Yu-Sun Lee Jae-Yong Kim Hyeong-Jun Park Seo-Hyeon Bae Hye-Jung Kim Yun-Hee Kim Hae Li Ko Sang-In Park Hun Kim Gyeongjoo Park Man-Seong Park Jun Chang Jae-Hwan Nam
author_sort	Yoo-Jin Bang
title	Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant
title_short	Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant
title_full	Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant
title_fullStr	Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant
title_full_unstemmed	Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant
title_sort	effective inactivated influenza vaccine for the elderly using a single-stranded rna-based adjuvant
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a5a57738d3804b2ea87a1b31eecaa317
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Effective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant

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