Nitrite-producing oral microbiome in adults and children
Abstract Recently, it was suggested that the nitrite (NO2 −) produced from NO3 − by oral bacteria might contribute to oral and general health. Therefore, we aimed to clarify the detailed information about the bacterial NO2-production in the oral biofilm. Dental plaque and tongue-coating samples were...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/a5aa5e47e9794da4bda5cd88ba354ed4 |
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| Sumario: | Abstract Recently, it was suggested that the nitrite (NO2 −) produced from NO3 − by oral bacteria might contribute to oral and general health. Therefore, we aimed to clarify the detailed information about the bacterial NO2-production in the oral biofilm. Dental plaque and tongue-coating samples were collected, then the NO2-producing activity was measured. Furthermore, the composition of the NO2 −-producing bacterial population were identified using the Griess reagent-containing agar overlay method and molecular biological method. NO2 −-producing activity per mg wet weight varied among individuals but was higher in dental plaque. Additionally, anaerobic bacteria exhibited higher numbers of NO2 −-producing bacteria, except in the adults’ dental plaque. The proportion of NO2 −-producing bacteria also varied among individuals, but a positive correlation was found between NO2 −-producing activity and the number of NO2 −-producing bacteria, especially in dental plaque. Overall, the major NO2 −-producing bacteria were identified as Actinomyces, Schaalia, Veillonella and Neisseria. Furthermore, Rothia was specifically detected in the tongue coatings of children. These results suggest that dental plaque has higher NO2 −-producing activity and that this activity depends not on the presence of specific bacteria or the bacterial compositions, but on the number of NO2 −-producing bacteria, although interindividual differences were detected. |
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