The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

DNA replication is initiated at defined genomic sites called origins of replication following ORC pre-replicative complex assembly. Here the authors identify a protein ubiquitylating ORC that is involved in origin activation and may act as a selector of origins to be fired.

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Autores principales: Philippe Coulombe, Joelle Nassar, Isabelle Peiffer, Slavica Stanojcic, Yvon Sterkers, Axel Delamarre, Stéphane Bocquet, Marcel Méchali
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/a5ac163b4ca344899aba6fd306311cef
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spelling oai:doaj.org-article:a5ac163b4ca344899aba6fd306311cef2021-12-02T16:57:10ZThe ORC ubiquitin ligase OBI1 promotes DNA replication origin firing10.1038/s41467-019-10321-x2041-1723https://doaj.org/article/a5ac163b4ca344899aba6fd306311cef2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10321-xhttps://doaj.org/toc/2041-1723DNA replication is initiated at defined genomic sites called origins of replication following ORC pre-replicative complex assembly. Here the authors identify a protein ubiquitylating ORC that is involved in origin activation and may act as a selector of origins to be fired.Philippe CoulombeJoelle NassarIsabelle PeifferSlavica StanojcicYvon SterkersAxel DelamarreStéphane BocquetMarcel MéchaliNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Philippe Coulombe
Joelle Nassar
Isabelle Peiffer
Slavica Stanojcic
Yvon Sterkers
Axel Delamarre
Stéphane Bocquet
Marcel Méchali
The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
description DNA replication is initiated at defined genomic sites called origins of replication following ORC pre-replicative complex assembly. Here the authors identify a protein ubiquitylating ORC that is involved in origin activation and may act as a selector of origins to be fired.
format article
author Philippe Coulombe
Joelle Nassar
Isabelle Peiffer
Slavica Stanojcic
Yvon Sterkers
Axel Delamarre
Stéphane Bocquet
Marcel Méchali
author_facet Philippe Coulombe
Joelle Nassar
Isabelle Peiffer
Slavica Stanojcic
Yvon Sterkers
Axel Delamarre
Stéphane Bocquet
Marcel Méchali
author_sort Philippe Coulombe
title The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
title_short The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
title_full The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
title_fullStr The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
title_full_unstemmed The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
title_sort orc ubiquitin ligase obi1 promotes dna replication origin firing
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/a5ac163b4ca344899aba6fd306311cef
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