The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

DNA replication is initiated at defined genomic sites called origins of replication following ORC pre-replicative complex assembly. Here the authors identify a protein ubiquitylating ORC that is involved in origin activation and may act as a selector of origins to be fired.

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Detalles Bibliográficos
Autores principales: Philippe Coulombe, Joelle Nassar, Isabelle Peiffer, Slavica Stanojcic, Yvon Sterkers, Axel Delamarre, Stéphane Bocquet, Marcel Méchali
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/a5ac163b4ca344899aba6fd306311cef
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