Preoperative Ultrasonography in the Evaluation of Suspected Familial Non-Medullary Thyroid Cancer: Are We Able to Predict Multifocality and Extrathyroidal Extension?

Family history of thyroid cancer increases the risk of harboring thyroid malignancies that end up having extrathyroidal extension (ETE) and multifocality on histology; some authors suggest a more aggressive surgical approach. Their pre-operative identification could allow more conservative surgical...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Giorgio Grani, Gianluca Cera, Giovanni Conzo, Valeria Del Gatto, Cira Rosaria Tiziana di Gioia, Marianna Maranghi, Piernatale Lucia, Vito Cantisani, Alessio Metere, Rossella Melcarne, Maria Carola Borcea, Chiara Scorziello, Rosa Menditto, Marco Summa, Marco Biffoni, Cosimo Durante, Laura Giacomelli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	TIRADS thyroid cancer thyroid nodules multifocality Medicine R
Acceso en línea:	https://doaj.org/article/a5ad259f716a4e2f9ac7c9eae27acc5d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a5ad259f716a4e2f9ac7c9eae27acc5d
record_format	dspace
spelling	oai:doaj.org-article:a5ad259f716a4e2f9ac7c9eae27acc5d2021-11-25T18:01:15ZPreoperative Ultrasonography in the Evaluation of Suspected Familial Non-Medullary Thyroid Cancer: Are We Able to Predict Multifocality and Extrathyroidal Extension?10.3390/jcm102252772077-0383https://doaj.org/article/a5ad259f716a4e2f9ac7c9eae27acc5d2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5277https://doaj.org/toc/2077-0383Family history of thyroid cancer increases the risk of harboring thyroid malignancies that end up having extrathyroidal extension (ETE) and multifocality on histology; some authors suggest a more aggressive surgical approach. Their pre-operative identification could allow more conservative surgical procedures if none of these features are suspected. Our aim was to assess if neck ultrasonography could identify or exclude multifocality or ETE in these patients to tailor the extent of surgery. This retrospective study included patients with previous thyroid surgery, ≥1 first-grade relative with thyroid cancer, and who had undergone pre-surgical ultrasound. ETE was suspected in the case of thyroid border interruption or gross invasion of perithyroidal tissues. Multiple suspicious nodules were defined as suspicion of multifocal cancer. The cohort consisted of 45 patients (median age 49 years, 40 with thyroid cancer, 30 females). The positive predictive value of ultrasonography in predicting multifocality and ETE was 57.14% (25.25–84.03) and 41.67% (21.5–65.1%), respectively, while the negative predictive values were 63.2% (56.4–69.4%) and 72.7% (63.3–80.5%). Pre-operative ultrasound examination is unable to reliably identify or exclude multifocal disease or extrathyroidal extension. In patients scheduled for surgery and with a first-degree relative affected by DTC, a “negative” pre-operative US report does not exclude the potential finding of multifocality and ETE at final histopathology.Giorgio GraniGianluca CeraGiovanni ConzoValeria Del GattoCira Rosaria Tiziana di GioiaMarianna MaranghiPiernatale LuciaVito CantisaniAlessio MetereRossella MelcarneMaria Carola BorceaChiara ScorzielloRosa MendittoMarco SummaMarco BiffoniCosimo DuranteLaura GiacomelliMDPI AGarticleTIRADSthyroid cancerthyroid nodulesmultifocalityMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5277, p 5277 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TIRADS thyroid cancer thyroid nodules multifocality Medicine R
spellingShingle	TIRADS thyroid cancer thyroid nodules multifocality Medicine R Giorgio Grani Gianluca Cera Giovanni Conzo Valeria Del Gatto Cira Rosaria Tiziana di Gioia Marianna Maranghi Piernatale Lucia Vito Cantisani Alessio Metere Rossella Melcarne Maria Carola Borcea Chiara Scorziello Rosa Menditto Marco Summa Marco Biffoni Cosimo Durante Laura Giacomelli Preoperative Ultrasonography in the Evaluation of Suspected Familial Non-Medullary Thyroid Cancer: Are We Able to Predict Multifocality and Extrathyroidal Extension?
description	Family history of thyroid cancer increases the risk of harboring thyroid malignancies that end up having extrathyroidal extension (ETE) and multifocality on histology; some authors suggest a more aggressive surgical approach. Their pre-operative identification could allow more conservative surgical procedures if none of these features are suspected. Our aim was to assess if neck ultrasonography could identify or exclude multifocality or ETE in these patients to tailor the extent of surgery. This retrospective study included patients with previous thyroid surgery, ≥1 first-grade relative with thyroid cancer, and who had undergone pre-surgical ultrasound. ETE was suspected in the case of thyroid border interruption or gross invasion of perithyroidal tissues. Multiple suspicious nodules were defined as suspicion of multifocal cancer. The cohort consisted of 45 patients (median age 49 years, 40 with thyroid cancer, 30 females). The positive predictive value of ultrasonography in predicting multifocality and ETE was 57.14% (25.25–84.03) and 41.67% (21.5–65.1%), respectively, while the negative predictive values were 63.2% (56.4–69.4%) and 72.7% (63.3–80.5%). Pre-operative ultrasound examination is unable to reliably identify or exclude multifocal disease or extrathyroidal extension. In patients scheduled for surgery and with a first-degree relative affected by DTC, a “negative” pre-operative US report does not exclude the potential finding of multifocality and ETE at final histopathology.
format	article
author	Giorgio Grani Gianluca Cera Giovanni Conzo Valeria Del Gatto Cira Rosaria Tiziana di Gioia Marianna Maranghi Piernatale Lucia Vito Cantisani Alessio Metere Rossella Melcarne Maria Carola Borcea Chiara Scorziello Rosa Menditto Marco Summa Marco Biffoni Cosimo Durante Laura Giacomelli
author_facet	Giorgio Grani Gianluca Cera Giovanni Conzo Valeria Del Gatto Cira Rosaria Tiziana di Gioia Marianna Maranghi Piernatale Lucia Vito Cantisani Alessio Metere Rossella Melcarne Maria Carola Borcea Chiara Scorziello Rosa Menditto Marco Summa Marco Biffoni Cosimo Durante Laura Giacomelli
author_sort	Giorgio Grani
title	Preoperative Ultrasonography in the Evaluation of Suspected Familial Non-Medullary Thyroid Cancer: Are We Able to Predict Multifocality and Extrathyroidal Extension?
title_short	Preoperative Ultrasonography in the Evaluation of Suspected Familial Non-Medullary Thyroid Cancer: Are We Able to Predict Multifocality and Extrathyroidal Extension?
title_full	Preoperative Ultrasonography in the Evaluation of Suspected Familial Non-Medullary Thyroid Cancer: Are We Able to Predict Multifocality and Extrathyroidal Extension?
title_fullStr	Preoperative Ultrasonography in the Evaluation of Suspected Familial Non-Medullary Thyroid Cancer: Are We Able to Predict Multifocality and Extrathyroidal Extension?
title_full_unstemmed	Preoperative Ultrasonography in the Evaluation of Suspected Familial Non-Medullary Thyroid Cancer: Are We Able to Predict Multifocality and Extrathyroidal Extension?
title_sort	preoperative ultrasonography in the evaluation of suspected familial non-medullary thyroid cancer: are we able to predict multifocality and extrathyroidal extension?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a5ad259f716a4e2f9ac7c9eae27acc5d
work_keys_str_mv	AT giorgiograni preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT gianlucacera preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT giovanniconzo preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT valeriadelgatto preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT cirarosariatizianadigioia preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT mariannamaranghi preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT piernatalelucia preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT vitocantisani preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT alessiometere preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT rossellamelcarne preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT mariacarolaborcea preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT chiarascorziello preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT rosamenditto preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT marcosumma preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT marcobiffoni preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT cosimodurante preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension AT lauragiacomelli preoperativeultrasonographyintheevaluationofsuspectedfamilialnonmedullarythyroidcancerareweabletopredictmultifocalityandextrathyroidalextension
_version_	1718411764826112000

Preoperative Ultrasonography in the Evaluation of Suspected Familial Non-Medullary Thyroid Cancer: Are We Able to Predict Multifocality and Extrathyroidal Extension?

Ejemplares similares