D-1 / PD-L1 EXPRESSION IN INVASIVE BREAST CARCINOMA / CANCER
Objective: To investigate the immunohistochemical expression of PD-1 and PD-L1 in breast cancer cases and its correlation with clinicopathological factors. Study Design: Cross sectional study. Place and Duration of Study: Histopathology department, Armed Forces Institute of Pathology Rawalpind...
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Army Medical College Rawalpindi
2021
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oai:doaj.org-article:a5b387f8089e48a0a25701bf882e3a222021-12-02T17:10:37ZD-1 / PD-L1 EXPRESSION IN INVASIVE BREAST CARCINOMA / CANCER0030-96482411-884210.51253/pafmj.v71i1.3128https://doaj.org/article/a5b387f8089e48a0a25701bf882e3a222021-02-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/3128https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To investigate the immunohistochemical expression of PD-1 and PD-L1 in breast cancer cases and its correlation with clinicopathological factors. Study Design: Cross sectional study. Place and Duration of Study: Histopathology department, Armed Forces Institute of Pathology Rawalpindi, form Jan to Jun 2019. Methodology: Sixty five cases of breast cancer were retrieved. Clinicopathological parameters like age, gender, tumor grade and receptor status were noted. Immunohistochemistry for PD-1 and PD-L1 was applied. The data was entered and statistical analysis was done using SPSS version 21. The associations between variables were found using the Fisher exact test. Results: Sixty five cases of breast cancer were investigated from tumour registry. The sample included female patients, having mean age of 50.86 ± 11.1 Years. Invasive mammary (ductal) carcinoma, NST was the most prevalent subtype 60 (92.3%) and most tumors were grade I/II 53(82%). PD-1 expression was seen in TIL’s 31 (48%) and PD-L1 expression was observed in tumour cells 30 (46%). Expression of PD-1/PD-L1 expression was more common in premenopausal age group and grade I/II tumors. Among molecular subtypes, PD-L1 expression was detected in 11 (52%) TNBC, 5 (71%) in HR-/HER2+ and 12 (32)% in HR + HER2 - and PD-1 expression was observed in 13 (62%) TNBC, 5 (71%) in HR-/HER2+ and 13 (35%) in HR+ HER2-. Conclusion: A large proportion of breast cancer cases show expression of PD-1 / PD-L1. Anti PD-1 and PD-L1 therapy may benefit these patients.Sammeen SalimMuhammad AsifRabia AhmedMuhammad Tahir KhadimArmy Medical College Rawalpindiarticleinvasive breast cancerprogrammed cell death protein 1programmed death-ligand 1MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 1, Pp 67-72 (2021) |
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| collection |
DOAJ |
| language |
EN |
| topic |
invasive breast cancer programmed cell death protein 1 programmed death-ligand 1 Medicine R Medicine (General) R5-920 |
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invasive breast cancer programmed cell death protein 1 programmed death-ligand 1 Medicine R Medicine (General) R5-920 Sammeen Salim Muhammad Asif Rabia Ahmed Muhammad Tahir Khadim D-1 / PD-L1 EXPRESSION IN INVASIVE BREAST CARCINOMA / CANCER |
| description |
Objective: To investigate the immunohistochemical expression of PD-1 and PD-L1 in breast cancer cases and its
correlation with clinicopathological factors.
Study Design: Cross sectional study.
Place and Duration of Study: Histopathology department, Armed Forces Institute of Pathology Rawalpindi, form Jan to Jun 2019.
Methodology: Sixty five cases of breast cancer were retrieved. Clinicopathological parameters like age, gender,
tumor grade and receptor status were noted. Immunohistochemistry for PD-1 and PD-L1 was applied. The data
was entered and statistical analysis was done using SPSS version 21. The associations between variables were
found using the Fisher exact test.
Results: Sixty five cases of breast cancer were investigated from tumour registry. The sample included female
patients, having mean age of 50.86 ± 11.1 Years. Invasive mammary (ductal) carcinoma, NST was the most prevalent subtype 60 (92.3%) and most tumors were grade I/II 53(82%). PD-1 expression was seen in TIL’s 31 (48%) and PD-L1 expression was observed in tumour cells 30 (46%). Expression of PD-1/PD-L1 expression was more common in premenopausal age group and grade I/II tumors. Among molecular subtypes, PD-L1 expression was detected in 11 (52%) TNBC, 5 (71%) in HR-/HER2+ and 12 (32)% in HR + HER2 - and PD-1 expression was observed in 13 (62%) TNBC, 5 (71%) in HR-/HER2+ and 13 (35%) in HR+ HER2-.
Conclusion: A large proportion of breast cancer cases show expression of PD-1 / PD-L1. Anti PD-1 and PD-L1
therapy may benefit these patients. |
| format |
article |
| author |
Sammeen Salim Muhammad Asif Rabia Ahmed Muhammad Tahir Khadim |
| author_facet |
Sammeen Salim Muhammad Asif Rabia Ahmed Muhammad Tahir Khadim |
| author_sort |
Sammeen Salim |
| title |
D-1 / PD-L1 EXPRESSION IN INVASIVE BREAST CARCINOMA / CANCER |
| title_short |
D-1 / PD-L1 EXPRESSION IN INVASIVE BREAST CARCINOMA / CANCER |
| title_full |
D-1 / PD-L1 EXPRESSION IN INVASIVE BREAST CARCINOMA / CANCER |
| title_fullStr |
D-1 / PD-L1 EXPRESSION IN INVASIVE BREAST CARCINOMA / CANCER |
| title_full_unstemmed |
D-1 / PD-L1 EXPRESSION IN INVASIVE BREAST CARCINOMA / CANCER |
| title_sort |
d-1 / pd-l1 expression in invasive breast carcinoma / cancer |
| publisher |
Army Medical College Rawalpindi |
| publishDate |
2021 |
| url |
https://doaj.org/article/a5b387f8089e48a0a25701bf882e3a22 |
| work_keys_str_mv |
AT sammeensalim d1pdl1expressionininvasivebreastcarcinomacancer AT muhammadasif d1pdl1expressionininvasivebreastcarcinomacancer AT rabiaahmed d1pdl1expressionininvasivebreastcarcinomacancer AT muhammadtahirkhadim d1pdl1expressionininvasivebreastcarcinomacancer |
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