Outer retina dysfunction and choriocapillaris impairment in type 1 diabetes

Abstract To study the outer retina morpho-functional characteristics and the choriocapillaris (CC) features in type 1 diabetic (T1D) patients, with and without signs of diabetic retinopathy (NPDR and NoDR). Twenty-five NPDR and 18 NoDR eyes were imaged by Optical Coherence Tomography Angiography. El...

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Autores principales:	M. Parravano, L. Ziccardi, E. Borrelli, E. Costanzo, S. Frontoni, F. Picconi, V. Parisi, R. Sacconi, A. Di Renzo, M. Varano, G. Querques
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a5b7e31eee6b40cfbfb1a933176ab7ce
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spelling	oai:doaj.org-article:a5b7e31eee6b40cfbfb1a933176ab7ce2021-12-02T16:13:47ZOuter retina dysfunction and choriocapillaris impairment in type 1 diabetes10.1038/s41598-021-94580-z2045-2322https://doaj.org/article/a5b7e31eee6b40cfbfb1a933176ab7ce2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94580-zhttps://doaj.org/toc/2045-2322Abstract To study the outer retina morpho-functional characteristics and the choriocapillaris (CC) features in type 1 diabetic (T1D) patients, with and without signs of diabetic retinopathy (NPDR and NoDR). Twenty-five NPDR and 18 NoDR eyes were imaged by Optical Coherence Tomography Angiography. Ellipsoid zone (EZ) “normalized” reflectivity and CC perfusion density parameters, as flow deficits number (FDn), flow deficit average area (FDa) and flow deficit percentage (FD%), were analysed. Multifocal electroretinogram (mfERG) response amplitude densities (RADs) were measured. Mean EZ “normalized” reflectivity, CC FDn and FD% values, were similar (p > 0.05) in both groups, FDa was significant greater (p > 0.05) in NPDR compared with NoDR eyes. MfERG-RADs were similar in both groups. NPDR eyes showed a significant (p < 0.05) linear correlation between RADs and both, CC FDa and FD%. The EZ “normalized” reflectivity was negatively correlated with CC FD% in NoDR eyes. In NPDR T1D eyes a significant relationship between abnormal outer retina functional responses and CC impairment was observed, while in NoDR eyes the photoreceptor reflectivity was correlated to CC abnormalities. The outer retina dysfunction in NPDR correlated to CC drop-out let hypothesize that the outer retinal elements are functionally impaired in proportion to the CC vascular supply deficit.M. ParravanoL. ZiccardiE. BorrelliE. CostanzoS. FrontoniF. PicconiV. ParisiR. SacconiA. Di RenzoM. VaranoG. QuerquesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Parravano L. Ziccardi E. Borrelli E. Costanzo S. Frontoni F. Picconi V. Parisi R. Sacconi A. Di Renzo M. Varano G. Querques Outer retina dysfunction and choriocapillaris impairment in type 1 diabetes
description	Abstract To study the outer retina morpho-functional characteristics and the choriocapillaris (CC) features in type 1 diabetic (T1D) patients, with and without signs of diabetic retinopathy (NPDR and NoDR). Twenty-five NPDR and 18 NoDR eyes were imaged by Optical Coherence Tomography Angiography. Ellipsoid zone (EZ) “normalized” reflectivity and CC perfusion density parameters, as flow deficits number (FDn), flow deficit average area (FDa) and flow deficit percentage (FD%), were analysed. Multifocal electroretinogram (mfERG) response amplitude densities (RADs) were measured. Mean EZ “normalized” reflectivity, CC FDn and FD% values, were similar (p > 0.05) in both groups, FDa was significant greater (p > 0.05) in NPDR compared with NoDR eyes. MfERG-RADs were similar in both groups. NPDR eyes showed a significant (p < 0.05) linear correlation between RADs and both, CC FDa and FD%. The EZ “normalized” reflectivity was negatively correlated with CC FD% in NoDR eyes. In NPDR T1D eyes a significant relationship between abnormal outer retina functional responses and CC impairment was observed, while in NoDR eyes the photoreceptor reflectivity was correlated to CC abnormalities. The outer retina dysfunction in NPDR correlated to CC drop-out let hypothesize that the outer retinal elements are functionally impaired in proportion to the CC vascular supply deficit.
format	article
author	M. Parravano L. Ziccardi E. Borrelli E. Costanzo S. Frontoni F. Picconi V. Parisi R. Sacconi A. Di Renzo M. Varano G. Querques
author_facet	M. Parravano L. Ziccardi E. Borrelli E. Costanzo S. Frontoni F. Picconi V. Parisi R. Sacconi A. Di Renzo M. Varano G. Querques
author_sort	M. Parravano
title	Outer retina dysfunction and choriocapillaris impairment in type 1 diabetes
title_short	Outer retina dysfunction and choriocapillaris impairment in type 1 diabetes
title_full	Outer retina dysfunction and choriocapillaris impairment in type 1 diabetes
title_fullStr	Outer retina dysfunction and choriocapillaris impairment in type 1 diabetes
title_full_unstemmed	Outer retina dysfunction and choriocapillaris impairment in type 1 diabetes
title_sort	outer retina dysfunction and choriocapillaris impairment in type 1 diabetes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a5b7e31eee6b40cfbfb1a933176ab7ce
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Outer retina dysfunction and choriocapillaris impairment in type 1 diabetes

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