The Risk of Psychological Stress on Cancer Recurrence: A Systematic Review

Cancer recurrence is a significant clinical issue in cancer treatment. Psychological stress has been known to contribute to the incidence and progression of cancer; however, its effect on cancer recurrence remains inconclusive. We conducted a systematic review to examine the current evidence from th...

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Autores principales:	Hyeon-Muk Oh, Chang-Gue Son
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	psychological stress life events cancer recurrence systematic review Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a5bc5633158a49c58023cb3fdbb09288
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spelling	oai:doaj.org-article:a5bc5633158a49c58023cb3fdbb092882021-11-25T17:04:21ZThe Risk of Psychological Stress on Cancer Recurrence: A Systematic Review10.3390/cancers132258162072-6694https://doaj.org/article/a5bc5633158a49c58023cb3fdbb092882021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5816https://doaj.org/toc/2072-6694Cancer recurrence is a significant clinical issue in cancer treatment. Psychological stress has been known to contribute to the incidence and progression of cancer; however, its effect on cancer recurrence remains inconclusive. We conducted a systematic review to examine the current evidence from the Medline (PubMed), Embase and Cochrane Library up to May 2021. Among 35 relevant articles, a total of 6 studies (10 data points) were finally selected, which enrolled 26,329 patients (26,219 breast cancer patients except hepatocellular carcinoma patients in 1 study), 4 cohort studies (8 data points) and 2 RCTs (2 data points). Among the 8 data points in cohort studies, four psychological stress-related factors (two ‘anxiety’, one ‘depression’, and one ‘hostility’) were shown to be moderately related with the risk for cancer recurrence, while ‘loss of partner’ resulted in opposite outcomes. The ‘emotional‘ and ‘mental’ health factors showed conflicting results, and an RCT-derived meta-analysis proved the positive efficiency of psychotherapies in reducing the cancer recurrence risk among breast cancer patients (HR = 0.52; 95% CI 0.33–0.84). Despite the limitations, this study produces comprehensive information about the effect of psychological stress on cancer recurrence and provides reference data to clinicians and scientists for further studies.Hyeon-Muk OhChang-Gue SonMDPI AGarticlepsychological stresslife eventscancer recurrencesystematic reviewNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5816, p 5816 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psychological stress life events cancer recurrence systematic review Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	psychological stress life events cancer recurrence systematic review Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hyeon-Muk Oh Chang-Gue Son The Risk of Psychological Stress on Cancer Recurrence: A Systematic Review
description	Cancer recurrence is a significant clinical issue in cancer treatment. Psychological stress has been known to contribute to the incidence and progression of cancer; however, its effect on cancer recurrence remains inconclusive. We conducted a systematic review to examine the current evidence from the Medline (PubMed), Embase and Cochrane Library up to May 2021. Among 35 relevant articles, a total of 6 studies (10 data points) were finally selected, which enrolled 26,329 patients (26,219 breast cancer patients except hepatocellular carcinoma patients in 1 study), 4 cohort studies (8 data points) and 2 RCTs (2 data points). Among the 8 data points in cohort studies, four psychological stress-related factors (two ‘anxiety’, one ‘depression’, and one ‘hostility’) were shown to be moderately related with the risk for cancer recurrence, while ‘loss of partner’ resulted in opposite outcomes. The ‘emotional‘ and ‘mental’ health factors showed conflicting results, and an RCT-derived meta-analysis proved the positive efficiency of psychotherapies in reducing the cancer recurrence risk among breast cancer patients (HR = 0.52; 95% CI 0.33–0.84). Despite the limitations, this study produces comprehensive information about the effect of psychological stress on cancer recurrence and provides reference data to clinicians and scientists for further studies.
format	article
author	Hyeon-Muk Oh Chang-Gue Son
author_facet	Hyeon-Muk Oh Chang-Gue Son
author_sort	Hyeon-Muk Oh
title	The Risk of Psychological Stress on Cancer Recurrence: A Systematic Review
title_short	The Risk of Psychological Stress on Cancer Recurrence: A Systematic Review
title_full	The Risk of Psychological Stress on Cancer Recurrence: A Systematic Review
title_fullStr	The Risk of Psychological Stress on Cancer Recurrence: A Systematic Review
title_full_unstemmed	The Risk of Psychological Stress on Cancer Recurrence: A Systematic Review
title_sort	risk of psychological stress on cancer recurrence: a systematic review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a5bc5633158a49c58023cb3fdbb09288
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The Risk of Psychological Stress on Cancer Recurrence: A Systematic Review

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