Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
Targeting the glycolytic PFKFB3 enzyme is being studied as a therapeutic strategy against cancer. Here the authors identify PFKFB3 as being involved in homologous recombination (HR) repair of DNA double strand breaks (DSBs) and present a PFKFB3 inhibitor.
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Nature Portfolio
2018
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oai:doaj.org-article:a5be37faa19d4d1fbbb9c428f096c5242021-12-02T16:49:35ZTargeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination10.1038/s41467-018-06287-x2041-1723https://doaj.org/article/a5be37faa19d4d1fbbb9c428f096c5242018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06287-xhttps://doaj.org/toc/2041-1723Targeting the glycolytic PFKFB3 enzyme is being studied as a therapeutic strategy against cancer. Here the authors identify PFKFB3 as being involved in homologous recombination (HR) repair of DNA double strand breaks (DSBs) and present a PFKFB3 inhibitor.Nina M. S. GustafssonKatarina FärnegårdhNadilly BonagasAnna Huguet NinouPetra GrothElisee WiitaMattias JönssonKenth HallbergJemina LehtoRosa PennisiJessica MartinssonCarina NorströmJessica HollersJohan SchultzMartin AnderssonNatalia MarkovaPetra MarttilaBaek KimMartin NorinThomas OlinThomas HelledayNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Nina M. S. Gustafsson Katarina Färnegårdh Nadilly Bonagas Anna Huguet Ninou Petra Groth Elisee Wiita Mattias Jönsson Kenth Hallberg Jemina Lehto Rosa Pennisi Jessica Martinsson Carina Norström Jessica Hollers Johan Schultz Martin Andersson Natalia Markova Petra Marttila Baek Kim Martin Norin Thomas Olin Thomas Helleday Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination |
| description |
Targeting the glycolytic PFKFB3 enzyme is being studied as a therapeutic strategy against cancer. Here the authors identify PFKFB3 as being involved in homologous recombination (HR) repair of DNA double strand breaks (DSBs) and present a PFKFB3 inhibitor. |
| format |
article |
| author |
Nina M. S. Gustafsson Katarina Färnegårdh Nadilly Bonagas Anna Huguet Ninou Petra Groth Elisee Wiita Mattias Jönsson Kenth Hallberg Jemina Lehto Rosa Pennisi Jessica Martinsson Carina Norström Jessica Hollers Johan Schultz Martin Andersson Natalia Markova Petra Marttila Baek Kim Martin Norin Thomas Olin Thomas Helleday |
| author_facet |
Nina M. S. Gustafsson Katarina Färnegårdh Nadilly Bonagas Anna Huguet Ninou Petra Groth Elisee Wiita Mattias Jönsson Kenth Hallberg Jemina Lehto Rosa Pennisi Jessica Martinsson Carina Norström Jessica Hollers Johan Schultz Martin Andersson Natalia Markova Petra Marttila Baek Kim Martin Norin Thomas Olin Thomas Helleday |
| author_sort |
Nina M. S. Gustafsson |
| title |
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination |
| title_short |
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination |
| title_full |
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination |
| title_fullStr |
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination |
| title_full_unstemmed |
Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination |
| title_sort |
targeting pfkfb3 radiosensitizes cancer cells and suppresses homologous recombination |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/a5be37faa19d4d1fbbb9c428f096c524 |
| work_keys_str_mv |
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| _version_ |
1718383295427772416 |