Stimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation.

Encoding of episodic memories relies on stimulus-specific information processing and involves the left prefrontal cortex. We here present an incidental finding from a simultaneous EEG-TMS experiment as well as a replication of this unexpected effect. Our results reveal that stimulating the left dors...

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Autores principales:	Mircea van der Plas, Verena Braun, Benjamin Johannes Stauch, Simon Hanslmayr
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a5bf6dcd3f4e414fbfe713805a76b393
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id	oai:doaj.org-article:a5bf6dcd3f4e414fbfe713805a76b393
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spelling	oai:doaj.org-article:a5bf6dcd3f4e414fbfe713805a76b3932021-12-02T19:54:34ZStimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation.1544-91731545-788510.1371/journal.pbio.3001363https://doaj.org/article/a5bf6dcd3f4e414fbfe713805a76b3932021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001363https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Encoding of episodic memories relies on stimulus-specific information processing and involves the left prefrontal cortex. We here present an incidental finding from a simultaneous EEG-TMS experiment as well as a replication of this unexpected effect. Our results reveal that stimulating the left dorsolateral prefrontal cortex (DLPFC) with slow repetitive transcranial magnetic stimulation (rTMS) leads to enhanced word memory performance. A total of 40 healthy human participants engaged in a list learning paradigm. Half of the participants (N = 20) received 1 Hz rTMS to the left DLPFC, while the other half (N = 20) received 1 Hz rTMS to the vertex and served as a control group. Participants receiving left DLPFC stimulation demonstrated enhanced memory performance compared to the control group. This effect was replicated in a within-subjects experiment where 24 participants received 1 Hz rTMS to the left DLPFC and vertex. In this second experiment, DLPFC stimulation also induced better memory performance compared to vertex stimulation. In addition to these behavioural effects, we found that 1 Hz rTMS to DLPFC induced stronger beta power modulation in posterior areas, a state that is known to be beneficial for memory encoding. Further analysis indicated that beta modulations did not have an oscillatory origin. Instead, the observed beta modulations were a result of a spectral tilt, suggesting inhibition of these parietal regions. These results show that applying 1 Hz rTMS to DLPFC, an area involved in episodic memory formation, improves memory performance via modulating neural activity in parietal regions.Mircea van der PlasVerena BraunBenjamin Johannes StauchSimon HanslmayrPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 9, p e3001363 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mircea van der Plas Verena Braun Benjamin Johannes Stauch Simon Hanslmayr Stimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation.
description	Encoding of episodic memories relies on stimulus-specific information processing and involves the left prefrontal cortex. We here present an incidental finding from a simultaneous EEG-TMS experiment as well as a replication of this unexpected effect. Our results reveal that stimulating the left dorsolateral prefrontal cortex (DLPFC) with slow repetitive transcranial magnetic stimulation (rTMS) leads to enhanced word memory performance. A total of 40 healthy human participants engaged in a list learning paradigm. Half of the participants (N = 20) received 1 Hz rTMS to the left DLPFC, while the other half (N = 20) received 1 Hz rTMS to the vertex and served as a control group. Participants receiving left DLPFC stimulation demonstrated enhanced memory performance compared to the control group. This effect was replicated in a within-subjects experiment where 24 participants received 1 Hz rTMS to the left DLPFC and vertex. In this second experiment, DLPFC stimulation also induced better memory performance compared to vertex stimulation. In addition to these behavioural effects, we found that 1 Hz rTMS to DLPFC induced stronger beta power modulation in posterior areas, a state that is known to be beneficial for memory encoding. Further analysis indicated that beta modulations did not have an oscillatory origin. Instead, the observed beta modulations were a result of a spectral tilt, suggesting inhibition of these parietal regions. These results show that applying 1 Hz rTMS to DLPFC, an area involved in episodic memory formation, improves memory performance via modulating neural activity in parietal regions.
format	article
author	Mircea van der Plas Verena Braun Benjamin Johannes Stauch Simon Hanslmayr
author_facet	Mircea van der Plas Verena Braun Benjamin Johannes Stauch Simon Hanslmayr
author_sort	Mircea van der Plas
title	Stimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation.
title_short	Stimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation.
title_full	Stimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation.
title_fullStr	Stimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation.
title_full_unstemmed	Stimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation.
title_sort	stimulation of the left dorsolateral prefrontal cortex with slow rtms enhances verbal memory formation.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a5bf6dcd3f4e414fbfe713805a76b393
work_keys_str_mv	AT mirceavanderplas stimulationoftheleftdorsolateralprefrontalcortexwithslowrtmsenhancesverbalmemoryformation AT verenabraun stimulationoftheleftdorsolateralprefrontalcortexwithslowrtmsenhancesverbalmemoryformation AT benjaminjohannesstauch stimulationoftheleftdorsolateralprefrontalcortexwithslowrtmsenhancesverbalmemoryformation AT simonhanslmayr stimulationoftheleftdorsolateralprefrontalcortexwithslowrtmsenhancesverbalmemoryformation
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Stimulation of the left dorsolateral prefrontal cortex with slow rTMS enhances verbal memory formation.

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