Association between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults

Abstract Recent studies have suggested that epigenetic alterations, particularly DNA methylation, play a crucial role in the pathogenesis of insulin resistance. Folate is a key source of the one-carbon group for DNA methylation, whereas the association and mechanistic linkage between folate status a...

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Autores principales:	Jinchao Li, Charlene E. Goh, Ryan T. Demmer, Brian W. Whitcomb, Peng Du, Zhenhua Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a5bf742badcb4227afe5d1bd6b32fd7c
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spelling	oai:doaj.org-article:a5bf742badcb4227afe5d1bd6b32fd7c2021-12-02T15:06:09ZAssociation between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults10.1038/s41598-017-09522-52045-2322https://doaj.org/article/a5bf742badcb4227afe5d1bd6b32fd7c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09522-5https://doaj.org/toc/2045-2322Abstract Recent studies have suggested that epigenetic alterations, particularly DNA methylation, play a crucial role in the pathogenesis of insulin resistance. Folate is a key source of the one-carbon group for DNA methylation, whereas the association and mechanistic linkage between folate status and insulin resistance remains unclear with very limited experimental support. We performed a cross-sectional study of 1530 nondiabetic adults in the 2011–2012 National Health and Nutrition Examination Survey (NHANES). We examined associations between serum folate and insulin resistance using multiple linear regression models adjusted for potential confounders. We detected a significant inverse relationship for serum folate, where a 25% increase in serum folate was associated with a 3.06% (95% CI, −4.72, −1.37) and 2.77% (95% CI, −4.36, −1.77) decline in HOMA-IR and insulin respectively, and a 2.55% (95% CI, 0.93, 4.21) increase in G/I ratio. Our findings demonstrate that serum folate was inversely associated with insulin resistance in U.S. nondiabetic adults.Jinchao LiCharlene E. GohRyan T. DemmerBrian W. WhitcombPeng DuZhenhua LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinchao Li Charlene E. Goh Ryan T. Demmer Brian W. Whitcomb Peng Du Zhenhua Liu Association between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults
description	Abstract Recent studies have suggested that epigenetic alterations, particularly DNA methylation, play a crucial role in the pathogenesis of insulin resistance. Folate is a key source of the one-carbon group for DNA methylation, whereas the association and mechanistic linkage between folate status and insulin resistance remains unclear with very limited experimental support. We performed a cross-sectional study of 1530 nondiabetic adults in the 2011–2012 National Health and Nutrition Examination Survey (NHANES). We examined associations between serum folate and insulin resistance using multiple linear regression models adjusted for potential confounders. We detected a significant inverse relationship for serum folate, where a 25% increase in serum folate was associated with a 3.06% (95% CI, −4.72, −1.37) and 2.77% (95% CI, −4.36, −1.77) decline in HOMA-IR and insulin respectively, and a 2.55% (95% CI, 0.93, 4.21) increase in G/I ratio. Our findings demonstrate that serum folate was inversely associated with insulin resistance in U.S. nondiabetic adults.
format	article
author	Jinchao Li Charlene E. Goh Ryan T. Demmer Brian W. Whitcomb Peng Du Zhenhua Liu
author_facet	Jinchao Li Charlene E. Goh Ryan T. Demmer Brian W. Whitcomb Peng Du Zhenhua Liu
author_sort	Jinchao Li
title	Association between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults
title_short	Association between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults
title_full	Association between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults
title_fullStr	Association between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults
title_full_unstemmed	Association between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults
title_sort	association between serum folate and insulin resistance among u.s. nondiabetic adults
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a5bf742badcb4227afe5d1bd6b32fd7c
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_version_	1718388601601916928

Association between Serum Folate and Insulin Resistance among U.S. Nondiabetic Adults

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