Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
Bacteria can be engineered to kill specific pathogens. Here, the authors modify and optimize a synthetic genetic system in a probiotic strain ofEscherichia coli, and show that the engineered probiotic can sense and kill the pathogen Pseudomonas aeruginosain two animal models of gut infection.
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| Main Authors: | , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2017
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| Subjects: | |
| Online Access: | https://doaj.org/article/a5c160db7f9b4ac99fc5558113c39f95 |
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| Summary: | Bacteria can be engineered to kill specific pathogens. Here, the authors modify and optimize a synthetic genetic system in a probiotic strain ofEscherichia coli, and show that the engineered probiotic can sense and kill the pathogen Pseudomonas aeruginosain two animal models of gut infection. |
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