Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

Bacteria can be engineered to kill specific pathogens. Here, the authors modify and optimize a synthetic genetic system in a probiotic strain ofEscherichia coli, and show that the engineered probiotic can sense and kill the pathogen Pseudomonas aeruginosain two animal models of gut infection.

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Autores principales:	In Young Hwang, Elvin Koh, Adison Wong, John C. March, William E. Bentley, Yung Seng Lee, Matthew Wook Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5c160db7f9b4ac99fc5558113c39f95
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spelling	oai:doaj.org-article:a5c160db7f9b4ac99fc5558113c39f952021-12-02T15:38:33ZEngineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models10.1038/ncomms150282041-1723https://doaj.org/article/a5c160db7f9b4ac99fc5558113c39f952017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15028https://doaj.org/toc/2041-1723Bacteria can be engineered to kill specific pathogens. Here, the authors modify and optimize a synthetic genetic system in a probiotic strain ofEscherichia coli, and show that the engineered probiotic can sense and kill the pathogen Pseudomonas aeruginosain two animal models of gut infection.In Young HwangElvin KohAdison WongJohn C. MarchWilliam E. BentleyYung Seng LeeMatthew Wook ChangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q In Young Hwang Elvin Koh Adison Wong John C. March William E. Bentley Yung Seng Lee Matthew Wook Chang Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
description	Bacteria can be engineered to kill specific pathogens. Here, the authors modify and optimize a synthetic genetic system in a probiotic strain ofEscherichia coli, and show that the engineered probiotic can sense and kill the pathogen Pseudomonas aeruginosain two animal models of gut infection.
format	article
author	In Young Hwang Elvin Koh Adison Wong John C. March William E. Bentley Yung Seng Lee Matthew Wook Chang
author_facet	In Young Hwang Elvin Koh Adison Wong John C. March William E. Bentley Yung Seng Lee Matthew Wook Chang
author_sort	In Young Hwang
title	Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
title_short	Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
title_full	Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
title_fullStr	Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
title_full_unstemmed	Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
title_sort	engineered probiotic escherichia coli can eliminate and prevent pseudomonas aeruginosa gut infection in animal models
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a5c160db7f9b4ac99fc5558113c39f95
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Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models

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