Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report

The use of steroids and other immune modulatory therapies in the treatment of severe COVID-19 pneumonia predisposes patients to the reemergence of opportunistic infections. Cytomegalovirus (CMV) reactivation can be one of them. A 55-year-old gentleman with severe COVID-19 pneumonia and hypoxic respi...

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Autores principales:	Dore C. Ananthegowda, Mohamad Y. Khatib, Husain S. Ali, Mohamed Al wraidat, Yahia Imam
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	CMV Meningoencephalitis Opportunistic infections COVID 19 Immunosuppression Steroids Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/a5c9b1a653b949529f968d0d6eaf0d13
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spelling	oai:doaj.org-article:a5c9b1a653b949529f968d0d6eaf0d132021-11-28T04:32:23ZCytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report2214-250910.1016/j.idcr.2021.e01346https://doaj.org/article/a5c9b1a653b949529f968d0d6eaf0d132021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214250921003024https://doaj.org/toc/2214-2509The use of steroids and other immune modulatory therapies in the treatment of severe COVID-19 pneumonia predisposes patients to the reemergence of opportunistic infections. Cytomegalovirus (CMV) reactivation can be one of them. A 55-year-old gentleman with severe COVID-19 pneumonia and hypoxic respiratory failure who was ventilated and received steroids but no other immunomodulatory drugs; had altered sensorium and multiple episodes of seizures in the later course of his illness. Brain MRI showed leptomeningeal enhancement and encephalopathy changes, electroencephalography (EEG) was suggestive of diffuse encephalopathy and his cerebrospinal fluid (CSF) analysis revealed high Cytomegalovirus PCR DNA titers (103,614). The patient made a complete recovery after treatment with Ganciclovir. Altered sensorium in cases of COVID-19 can be multifactorial. High index of suspicion for reactivation of dormant infections is warranted. CMV meningoencephalitis is one of the differential diagnoses. We believe this is the first case reported of CMV meningoencephalitis in the setting of severe COVID-19 infection.Dore C. AnanthegowdaMohamad Y. KhatibHusain S. AliMohamed Al wraidatYahia ImamElsevierarticleCMVMeningoencephalitisOpportunistic infectionsCOVID 19ImmunosuppressionSteroidsInfectious and parasitic diseasesRC109-216ENIDCases, Vol 26, Iss , Pp e01346- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CMV Meningoencephalitis Opportunistic infections COVID 19 Immunosuppression Steroids Infectious and parasitic diseases RC109-216
spellingShingle	CMV Meningoencephalitis Opportunistic infections COVID 19 Immunosuppression Steroids Infectious and parasitic diseases RC109-216 Dore C. Ananthegowda Mohamad Y. Khatib Husain S. Ali Mohamed Al wraidat Yahia Imam Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report
description	The use of steroids and other immune modulatory therapies in the treatment of severe COVID-19 pneumonia predisposes patients to the reemergence of opportunistic infections. Cytomegalovirus (CMV) reactivation can be one of them. A 55-year-old gentleman with severe COVID-19 pneumonia and hypoxic respiratory failure who was ventilated and received steroids but no other immunomodulatory drugs; had altered sensorium and multiple episodes of seizures in the later course of his illness. Brain MRI showed leptomeningeal enhancement and encephalopathy changes, electroencephalography (EEG) was suggestive of diffuse encephalopathy and his cerebrospinal fluid (CSF) analysis revealed high Cytomegalovirus PCR DNA titers (103,614). The patient made a complete recovery after treatment with Ganciclovir. Altered sensorium in cases of COVID-19 can be multifactorial. High index of suspicion for reactivation of dormant infections is warranted. CMV meningoencephalitis is one of the differential diagnoses. We believe this is the first case reported of CMV meningoencephalitis in the setting of severe COVID-19 infection.
format	article
author	Dore C. Ananthegowda Mohamad Y. Khatib Husain S. Ali Mohamed Al wraidat Yahia Imam
author_facet	Dore C. Ananthegowda Mohamad Y. Khatib Husain S. Ali Mohamed Al wraidat Yahia Imam
author_sort	Dore C. Ananthegowda
title	Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report
title_short	Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report
title_full	Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report
title_fullStr	Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report
title_full_unstemmed	Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report
title_sort	cytomegalovirus meningoencephalitis in a case of severe covid-19 pneumonia. a case report
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a5c9b1a653b949529f968d0d6eaf0d13
work_keys_str_mv	AT dorecananthegowda cytomegalovirusmeningoencephalitisinacaseofseverecovid19pneumoniaacasereport AT mohamadykhatib cytomegalovirusmeningoencephalitisinacaseofseverecovid19pneumoniaacasereport AT husainsali cytomegalovirusmeningoencephalitisinacaseofseverecovid19pneumoniaacasereport AT mohamedalwraidat cytomegalovirusmeningoencephalitisinacaseofseverecovid19pneumoniaacasereport AT yahiaimam cytomegalovirusmeningoencephalitisinacaseofseverecovid19pneumoniaacasereport
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Cytomegalovirus meningoencephalitis in a case of severe COVID-19 Pneumonia. A case report

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