Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome

Abstract Over the course of a mission to the International Space Station (ISS) crew members are exposed to a number of stressors that can potentially alter the composition of their microbiomes and may have a negative impact on astronauts’ health. Here we investigated the impact of long-term space ex...

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Autores principales:	Alexander A. Voorhies, C. Mark Ott, Satish Mehta, Duane L. Pierson, Brian E. Crucian, Alan Feiveson, Cherie M. Oubre, Manolito Torralba, Kelvin Moncera, Yun Zhang, Eduardo Zurek, Hernan A. Lorenzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a5cf7868343a469e881872fed67500f3
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spelling	oai:doaj.org-article:a5cf7868343a469e881872fed67500f32021-12-02T15:09:32ZStudy of the impact of long-duration space missions at the International Space Station on the astronaut microbiome10.1038/s41598-019-46303-82045-2322https://doaj.org/article/a5cf7868343a469e881872fed67500f32019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46303-8https://doaj.org/toc/2045-2322Abstract Over the course of a mission to the International Space Station (ISS) crew members are exposed to a number of stressors that can potentially alter the composition of their microbiomes and may have a negative impact on astronauts’ health. Here we investigated the impact of long-term space exploration on the microbiome of nine astronauts that spent six to twelve months in the ISS. We present evidence showing that the microbial communities of the gastrointestinal tract, skin, nose and tongue change during the space mission. The composition of the intestinal microbiota became more similar across astronauts in space, mostly due to a drop in the abundance of a few bacterial taxa, some of which were also correlated with changes in the cytokine profile of crewmembers. Alterations in the skin microbiome that might contribute to the high frequency of skin rashes/hypersensitivity episodes experienced by astronauts in space were also observed. The results from this study demonstrate that the composition of the astronauts’ microbiome is altered during space travel. The impact of those changes on crew health warrants further investigation before humans embark on long-duration voyages into outer space.Alexander A. VoorhiesC. Mark OttSatish MehtaDuane L. PiersonBrian E. CrucianAlan FeivesonCherie M. OubreManolito TorralbaKelvin MonceraYun ZhangEduardo ZurekHernan A. LorenziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander A. Voorhies C. Mark Ott Satish Mehta Duane L. Pierson Brian E. Crucian Alan Feiveson Cherie M. Oubre Manolito Torralba Kelvin Moncera Yun Zhang Eduardo Zurek Hernan A. Lorenzi Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome
description	Abstract Over the course of a mission to the International Space Station (ISS) crew members are exposed to a number of stressors that can potentially alter the composition of their microbiomes and may have a negative impact on astronauts’ health. Here we investigated the impact of long-term space exploration on the microbiome of nine astronauts that spent six to twelve months in the ISS. We present evidence showing that the microbial communities of the gastrointestinal tract, skin, nose and tongue change during the space mission. The composition of the intestinal microbiota became more similar across astronauts in space, mostly due to a drop in the abundance of a few bacterial taxa, some of which were also correlated with changes in the cytokine profile of crewmembers. Alterations in the skin microbiome that might contribute to the high frequency of skin rashes/hypersensitivity episodes experienced by astronauts in space were also observed. The results from this study demonstrate that the composition of the astronauts’ microbiome is altered during space travel. The impact of those changes on crew health warrants further investigation before humans embark on long-duration voyages into outer space.
format	article
author	Alexander A. Voorhies C. Mark Ott Satish Mehta Duane L. Pierson Brian E. Crucian Alan Feiveson Cherie M. Oubre Manolito Torralba Kelvin Moncera Yun Zhang Eduardo Zurek Hernan A. Lorenzi
author_facet	Alexander A. Voorhies C. Mark Ott Satish Mehta Duane L. Pierson Brian E. Crucian Alan Feiveson Cherie M. Oubre Manolito Torralba Kelvin Moncera Yun Zhang Eduardo Zurek Hernan A. Lorenzi
author_sort	Alexander A. Voorhies
title	Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome
title_short	Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome
title_full	Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome
title_fullStr	Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome
title_full_unstemmed	Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome
title_sort	study of the impact of long-duration space missions at the international space station on the astronaut microbiome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a5cf7868343a469e881872fed67500f3
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Study of the impact of long-duration space missions at the International Space Station on the astronaut microbiome

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