Oral vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis Bacillus Calmette-Guerin (BCG).

Wildlife reservoirs of Mycobacterium bovis represent serious obstacles to the eradication of tuberculosis from livestock, particularly cattle. In Michigan, USA tuberculous white-tailed deer transmit M. bovis to other deer and cattle. One approach in dealing with this wildlife reservoir is to vaccina...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mitchell V Palmer, Tyler C Thacker, W Ray Waters, Suelee Robbe-Austerman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a5d28f25dd6b4f6cbd92c11d9be87ac5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a5d28f25dd6b4f6cbd92c11d9be87ac5
record_format	dspace
spelling	oai:doaj.org-article:a5d28f25dd6b4f6cbd92c11d9be87ac52021-11-18T08:20:28ZOral vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis Bacillus Calmette-Guerin (BCG).1932-620310.1371/journal.pone.0097031https://doaj.org/article/a5d28f25dd6b4f6cbd92c11d9be87ac52014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24804678/?tool=EBIhttps://doaj.org/toc/1932-6203Wildlife reservoirs of Mycobacterium bovis represent serious obstacles to the eradication of tuberculosis from livestock, particularly cattle. In Michigan, USA tuberculous white-tailed deer transmit M. bovis to other deer and cattle. One approach in dealing with this wildlife reservoir is to vaccinate deer, thus interfering with the intraspecies and interspecies transmission cycles. Thirty-three white-tailed deer were assigned to one of two groups; oral vaccination with 1 × 10(8) colony-forming units of M. bovis BCG Danish (n = 17); and non-vaccinated (n = 16). One hundred eleven days after vaccination deer were infected intratonsilarly with 300 colony-forming units of virulent M. bovis. At examination, 150 days after challenge, BCG vaccinated deer had fewer gross and microscopic lesions, fewer tissues from which M. bovis could be isolated, and fewer late stage granulomas with extensive liquefactive necrosis. Fewer lesions, especially those of a highly necrotic nature should decrease the potential for dissemination of M. bovis within the host and transmission to other susceptible hosts.Mitchell V PalmerTyler C ThackerW Ray WatersSuelee Robbe-AustermanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e97031 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mitchell V Palmer Tyler C Thacker W Ray Waters Suelee Robbe-Austerman Oral vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis Bacillus Calmette-Guerin (BCG).
description	Wildlife reservoirs of Mycobacterium bovis represent serious obstacles to the eradication of tuberculosis from livestock, particularly cattle. In Michigan, USA tuberculous white-tailed deer transmit M. bovis to other deer and cattle. One approach in dealing with this wildlife reservoir is to vaccinate deer, thus interfering with the intraspecies and interspecies transmission cycles. Thirty-three white-tailed deer were assigned to one of two groups; oral vaccination with 1 × 10(8) colony-forming units of M. bovis BCG Danish (n = 17); and non-vaccinated (n = 16). One hundred eleven days after vaccination deer were infected intratonsilarly with 300 colony-forming units of virulent M. bovis. At examination, 150 days after challenge, BCG vaccinated deer had fewer gross and microscopic lesions, fewer tissues from which M. bovis could be isolated, and fewer late stage granulomas with extensive liquefactive necrosis. Fewer lesions, especially those of a highly necrotic nature should decrease the potential for dissemination of M. bovis within the host and transmission to other susceptible hosts.
format	article
author	Mitchell V Palmer Tyler C Thacker W Ray Waters Suelee Robbe-Austerman
author_facet	Mitchell V Palmer Tyler C Thacker W Ray Waters Suelee Robbe-Austerman
author_sort	Mitchell V Palmer
title	Oral vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis Bacillus Calmette-Guerin (BCG).
title_short	Oral vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis Bacillus Calmette-Guerin (BCG).
title_full	Oral vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis Bacillus Calmette-Guerin (BCG).
title_fullStr	Oral vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis Bacillus Calmette-Guerin (BCG).
title_full_unstemmed	Oral vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis Bacillus Calmette-Guerin (BCG).
title_sort	oral vaccination of white-tailed deer (odocoileus virginianus) with mycobacterium bovis bacillus calmette-guerin (bcg).
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/a5d28f25dd6b4f6cbd92c11d9be87ac5
work_keys_str_mv	AT mitchellvpalmer oralvaccinationofwhitetaileddeerodocoileusvirginianuswithmycobacteriumbovisbacilluscalmetteguerinbcg AT tylercthacker oralvaccinationofwhitetaileddeerodocoileusvirginianuswithmycobacteriumbovisbacilluscalmetteguerinbcg AT wraywaters oralvaccinationofwhitetaileddeerodocoileusvirginianuswithmycobacteriumbovisbacilluscalmetteguerinbcg AT sueleerobbeausterman oralvaccinationofwhitetaileddeerodocoileusvirginianuswithmycobacteriumbovisbacilluscalmetteguerinbcg
_version_	1718421878545055744

Oral vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis Bacillus Calmette-Guerin (BCG).

Ejemplares similares