Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms

Mother Nature is a valuable resource for the discovery of drug and agricultural chemicals. Here, the authors show that 7-deoxy-sedoheptulose produced by a cyanobacterium is an antimicrobial and herbicidal compound that acts through inhibition of 3-dehydroquniate synthase in the shikimate pathway.

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Autores principales:	Klaus Brilisauer, Johanna Rapp, Pascal Rath, Anna Schöllhorn, Lisa Bleul, Elisabeth Weiß, Mark Stahl, Stephanie Grond, Karl Forchhammer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5d87f53fecd497cbbfde34ff9f3664a
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spelling	oai:doaj.org-article:a5d87f53fecd497cbbfde34ff9f3664a2021-12-02T14:39:19ZCyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms10.1038/s41467-019-08476-82041-1723https://doaj.org/article/a5d87f53fecd497cbbfde34ff9f3664a2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08476-8https://doaj.org/toc/2041-1723Mother Nature is a valuable resource for the discovery of drug and agricultural chemicals. Here, the authors show that 7-deoxy-sedoheptulose produced by a cyanobacterium is an antimicrobial and herbicidal compound that acts through inhibition of 3-dehydroquniate synthase in the shikimate pathway.Klaus BrilisauerJohanna RappPascal RathAnna SchöllhornLisa BleulElisabeth WeißMark StahlStephanie GrondKarl ForchhammerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Klaus Brilisauer Johanna Rapp Pascal Rath Anna Schöllhorn Lisa Bleul Elisabeth Weiß Mark Stahl Stephanie Grond Karl Forchhammer Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms
description	Mother Nature is a valuable resource for the discovery of drug and agricultural chemicals. Here, the authors show that 7-deoxy-sedoheptulose produced by a cyanobacterium is an antimicrobial and herbicidal compound that acts through inhibition of 3-dehydroquniate synthase in the shikimate pathway.
format	article
author	Klaus Brilisauer Johanna Rapp Pascal Rath Anna Schöllhorn Lisa Bleul Elisabeth Weiß Mark Stahl Stephanie Grond Karl Forchhammer
author_facet	Klaus Brilisauer Johanna Rapp Pascal Rath Anna Schöllhorn Lisa Bleul Elisabeth Weiß Mark Stahl Stephanie Grond Karl Forchhammer
author_sort	Klaus Brilisauer
title	Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms
title_short	Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms
title_full	Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms
title_fullStr	Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms
title_full_unstemmed	Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms
title_sort	cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a5d87f53fecd497cbbfde34ff9f3664a
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Cyanobacterial antimetabolite 7-deoxy-sedoheptulose blocks the shikimate pathway to inhibit the growth of prototrophic organisms

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