Nucleotide Resolution Comparison of Transcription of Human Cytomegalovirus and Host Genomes Reveals Universal Use of RNA Polymerase II Elongation Control Driven by Dissimilar Core Promoter Elements

Nucleotide Resolution Comparison of Transcription of Human Cytomegalovirus and Host Genomes Reveals Universal Use of RNA Polymerase II Elongation Control Driven by Dissimilar Core Promoter Elements

ABSTRACT The large genome of human cytomegalovirus (HCMV) is transcribed by RNA polymerase II (Pol II). However, it is not known how closely this betaherpesvirus follows host transcriptional paradigms. We applied PRO-Seq and PRO-Cap methods to profile and quantify transcription initiation and produc...

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Autores principales: Mrutyunjaya Parida, Kyle A. Nilson, Ming Li, Christopher B. Ball, Harrison A. Fuchs, Christine K. Lawson, Donal S. Luse, Jeffery L. Meier, David H. Price
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
core promoter elements
P-TEFb
PRO-Seq
RNA polymerase II
RNA4.9
cytomegalovirus
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/a5da4a0ae2b2409fbf8c0b9a8da26b4e
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