Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells

Adipose tissue hypertrophy in obesity is associated with insulin resistance and other metabolic complications. Here, the authors analyze subcutaneous adipose tissue from patients with hypertrophic obesity and insulin resistance and find that adipocyte progenitor cells show features of senescence and...

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Autores principales:	Birgit Gustafson, Annika Nerstedt, Ulf Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5de7224b22546db86b2f0bcdb112ada
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spelling	oai:doaj.org-article:a5de7224b22546db86b2f0bcdb112ada2021-12-02T17:01:54ZReduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells10.1038/s41467-019-10688-x2041-1723https://doaj.org/article/a5de7224b22546db86b2f0bcdb112ada2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10688-xhttps://doaj.org/toc/2041-1723Adipose tissue hypertrophy in obesity is associated with insulin resistance and other metabolic complications. Here, the authors analyze subcutaneous adipose tissue from patients with hypertrophic obesity and insulin resistance and find that adipocyte progenitor cells show features of senescence and have poor differentiation capacity.Birgit GustafsonAnnika NerstedtUlf SmithNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Birgit Gustafson Annika Nerstedt Ulf Smith Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
description	Adipose tissue hypertrophy in obesity is associated with insulin resistance and other metabolic complications. Here, the authors analyze subcutaneous adipose tissue from patients with hypertrophic obesity and insulin resistance and find that adipocyte progenitor cells show features of senescence and have poor differentiation capacity.
format	article
author	Birgit Gustafson Annika Nerstedt Ulf Smith
author_facet	Birgit Gustafson Annika Nerstedt Ulf Smith
author_sort	Birgit Gustafson
title	Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
title_short	Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
title_full	Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
title_fullStr	Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
title_full_unstemmed	Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
title_sort	reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a5de7224b22546db86b2f0bcdb112ada
work_keys_str_mv	AT birgitgustafson reducedsubcutaneousadipogenesisinhumanhypertrophicobesityislinkedtosenescentprecursorcells AT annikanerstedt reducedsubcutaneousadipogenesisinhumanhypertrophicobesityislinkedtosenescentprecursorcells AT ulfsmith reducedsubcutaneousadipogenesisinhumanhypertrophicobesityislinkedtosenescentprecursorcells
_version_	1718382043942879232

Reduced subcutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells

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