Predicting the onset of anxiety syndromes at 12 months in primary care attendees. The predictA-Spain study.
<h4>Background</h4>There are no risk algorithms for the onset of anxiety syndromes at 12 months in primary care. We aimed to develop and validate internally a risk algorithm to predict the onset of anxiety syndromes at 12 months.<h4>Methods</h4>A prospective cohort study with...
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2014
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oai:doaj.org-article:a5e0abf7964044a58f52081694ee9e2d2021-11-25T06:02:05ZPredicting the onset of anxiety syndromes at 12 months in primary care attendees. The predictA-Spain study.1932-620310.1371/journal.pone.0106370https://doaj.org/article/a5e0abf7964044a58f52081694ee9e2d2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25184313/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>There are no risk algorithms for the onset of anxiety syndromes at 12 months in primary care. We aimed to develop and validate internally a risk algorithm to predict the onset of anxiety syndromes at 12 months.<h4>Methods</h4>A prospective cohort study with evaluations at baseline, 6 and 12 months. We measured 39 known risk factors and used multilevel logistic regression and inverse probability weighting to build the risk algorithm. Our main outcome was generalized anxiety, panic and other non-specific anxiety syndromes as measured by the Primary Care Evaluation of Mental Disorders, Patient Health Questionnaire (PRIME-MD-PHQ). We recruited 3,564 adult primary care attendees without anxiety syndromes from 174 family physicians and 32 health centers in 6 Spanish provinces.<h4>Results</h4>The cumulative 12-month incidence of anxiety syndromes was 12.2%. The predictA-Spain risk algorithm included the following predictors of anxiety syndromes: province; sex (female); younger age; taking medicines for anxiety, depression or stress; worse physical and mental quality of life (SF-12); dissatisfaction with paid and unpaid work; perception of financial strain; and the interactions sex*age, sex*perception of financial strain, and age*dissatisfaction with paid work. The C-index was 0.80 (95% confidence interval=0.78-0.83) and the Hedges' g=1.17 (95% confidence interval=1.04-1.29). The Copas shrinkage factor was 0.98 and calibration plots showed an accurate goodness of fit.<h4>Conclusions</h4>The predictA-Spain risk algorithm is valid to predict anxiety syndromes at 12 months. Although external validation is required, the predictA-Spain is available for use as a predictive tool in the prevention of anxiety syndromes in primary care.Patricia Moreno-PeralJuan de Dios LunaLouise MarstonMichael KingIrwin NazarethEmma MotricoMaría Josefa GildeGómez-BarragánFrancisco Torres-GonzálezCarmen Montón-FrancoMarta Sánchez-CelayaMiguel Ángel Díaz-BarreirosCatalina VicensCarlos Muñoz-BravoJuan Ángel BellónPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e106370 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Patricia Moreno-Peral Juan de Dios Luna Louise Marston Michael King Irwin Nazareth Emma Motrico María Josefa GildeGómez-Barragán Francisco Torres-González Carmen Montón-Franco Marta Sánchez-Celaya Miguel Ángel Díaz-Barreiros Catalina Vicens Carlos Muñoz-Bravo Juan Ángel Bellón Predicting the onset of anxiety syndromes at 12 months in primary care attendees. The predictA-Spain study. |
| description |
<h4>Background</h4>There are no risk algorithms for the onset of anxiety syndromes at 12 months in primary care. We aimed to develop and validate internally a risk algorithm to predict the onset of anxiety syndromes at 12 months.<h4>Methods</h4>A prospective cohort study with evaluations at baseline, 6 and 12 months. We measured 39 known risk factors and used multilevel logistic regression and inverse probability weighting to build the risk algorithm. Our main outcome was generalized anxiety, panic and other non-specific anxiety syndromes as measured by the Primary Care Evaluation of Mental Disorders, Patient Health Questionnaire (PRIME-MD-PHQ). We recruited 3,564 adult primary care attendees without anxiety syndromes from 174 family physicians and 32 health centers in 6 Spanish provinces.<h4>Results</h4>The cumulative 12-month incidence of anxiety syndromes was 12.2%. The predictA-Spain risk algorithm included the following predictors of anxiety syndromes: province; sex (female); younger age; taking medicines for anxiety, depression or stress; worse physical and mental quality of life (SF-12); dissatisfaction with paid and unpaid work; perception of financial strain; and the interactions sex*age, sex*perception of financial strain, and age*dissatisfaction with paid work. The C-index was 0.80 (95% confidence interval=0.78-0.83) and the Hedges' g=1.17 (95% confidence interval=1.04-1.29). The Copas shrinkage factor was 0.98 and calibration plots showed an accurate goodness of fit.<h4>Conclusions</h4>The predictA-Spain risk algorithm is valid to predict anxiety syndromes at 12 months. Although external validation is required, the predictA-Spain is available for use as a predictive tool in the prevention of anxiety syndromes in primary care. |
| format |
article |
| author |
Patricia Moreno-Peral Juan de Dios Luna Louise Marston Michael King Irwin Nazareth Emma Motrico María Josefa GildeGómez-Barragán Francisco Torres-González Carmen Montón-Franco Marta Sánchez-Celaya Miguel Ángel Díaz-Barreiros Catalina Vicens Carlos Muñoz-Bravo Juan Ángel Bellón |
| author_facet |
Patricia Moreno-Peral Juan de Dios Luna Louise Marston Michael King Irwin Nazareth Emma Motrico María Josefa GildeGómez-Barragán Francisco Torres-González Carmen Montón-Franco Marta Sánchez-Celaya Miguel Ángel Díaz-Barreiros Catalina Vicens Carlos Muñoz-Bravo Juan Ángel Bellón |
| author_sort |
Patricia Moreno-Peral |
| title |
Predicting the onset of anxiety syndromes at 12 months in primary care attendees. The predictA-Spain study. |
| title_short |
Predicting the onset of anxiety syndromes at 12 months in primary care attendees. The predictA-Spain study. |
| title_full |
Predicting the onset of anxiety syndromes at 12 months in primary care attendees. The predictA-Spain study. |
| title_fullStr |
Predicting the onset of anxiety syndromes at 12 months in primary care attendees. The predictA-Spain study. |
| title_full_unstemmed |
Predicting the onset of anxiety syndromes at 12 months in primary care attendees. The predictA-Spain study. |
| title_sort |
predicting the onset of anxiety syndromes at 12 months in primary care attendees. the predicta-spain study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/a5e0abf7964044a58f52081694ee9e2d |
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