Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism

Antibiotic-induced microbiome depletion is one of the most common approaches to modulate the gut microbiome. Here the authors demonstrate that it affects gut homeostasis and glucose metabolism by decreasing luminal short chain fatty acids and leading to a shift of energy utilization by colonocytes.

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Auteurs principaux:	Amir Zarrinpar, Amandine Chaix, Zhenjiang Z. Xu, Max W. Chang, Clarisse A. Marotz, Alan Saghatelian, Rob Knight, Satchidananda Panda
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/a5e2a93dd23c4ffd9f9cfa80ad8db294
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spelling	oai:doaj.org-article:a5e2a93dd23c4ffd9f9cfa80ad8db2942021-12-02T13:27:23ZAntibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism10.1038/s41467-018-05336-92041-1723https://doaj.org/article/a5e2a93dd23c4ffd9f9cfa80ad8db2942018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05336-9https://doaj.org/toc/2041-1723Antibiotic-induced microbiome depletion is one of the most common approaches to modulate the gut microbiome. Here the authors demonstrate that it affects gut homeostasis and glucose metabolism by decreasing luminal short chain fatty acids and leading to a shift of energy utilization by colonocytes.Amir ZarrinparAmandine ChaixZhenjiang Z. XuMax W. ChangClarisse A. MarotzAlan SaghatelianRob KnightSatchidananda PandaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amir Zarrinpar Amandine Chaix Zhenjiang Z. Xu Max W. Chang Clarisse A. Marotz Alan Saghatelian Rob Knight Satchidananda Panda Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
description	Antibiotic-induced microbiome depletion is one of the most common approaches to modulate the gut microbiome. Here the authors demonstrate that it affects gut homeostasis and glucose metabolism by decreasing luminal short chain fatty acids and leading to a shift of energy utilization by colonocytes.
format	article
author	Amir Zarrinpar Amandine Chaix Zhenjiang Z. Xu Max W. Chang Clarisse A. Marotz Alan Saghatelian Rob Knight Satchidananda Panda
author_facet	Amir Zarrinpar Amandine Chaix Zhenjiang Z. Xu Max W. Chang Clarisse A. Marotz Alan Saghatelian Rob Knight Satchidananda Panda
author_sort	Amir Zarrinpar
title	Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
title_short	Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
title_full	Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
title_fullStr	Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
title_full_unstemmed	Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
title_sort	antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a5e2a93dd23c4ffd9f9cfa80ad8db294
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Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism

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