Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress

Hepatic fibrosis is the final pathway of several chronic liver diseases, which is characterized by the accumulation of extracellular matrix due to chronic hepatocyte damage. Activation of hepatic stellate cells and oxidative stress (OS) play an important role in mediating liver damage and initiating...

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Autores principales:	Wenzhang Dai, Qin Qin, Zhiyong Li, Li Lin, Ruisheng Li, Zhie Fang, Yanzhong Han, Wenqing Mu, Lutong Ren, Tingting Liu, Xiaoyan Zhan, Xiaohe Xiao, Zhaofang Bai
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	schisandrin C Curdione hepatic fibrosis oxidative stress TGF-β1/Smads signaling pathway Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a5e4b0dbbebf418cac2300267bcab8a7
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spelling	oai:doaj.org-article:a5e4b0dbbebf418cac2300267bcab8a72021-11-10T07:25:17ZCurdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress2296-634X10.3389/fcell.2021.763864https://doaj.org/article/a5e4b0dbbebf418cac2300267bcab8a72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.763864/fullhttps://doaj.org/toc/2296-634XHepatic fibrosis is the final pathway of several chronic liver diseases, which is characterized by the accumulation of extracellular matrix due to chronic hepatocyte damage. Activation of hepatic stellate cells and oxidative stress (OS) play an important role in mediating liver damage and initiating hepatic fibrosis. Hence, hepatic fibrosis can be reversed by inhibiting multiple channels such as oxidative stress, liver cell damage, or activation of hepatic stellate cells. Liuwei Wuling Tablets is a traditional Chinese medicine formula with the effect of anti- hepatic fibrosis, but the composition and mechanism of reversing hepatic fibrosis are still unclear. Our study demonstrated that one of the main active components of the Chinese medicine Schisandra chinensis, schisandrin C (Sin C), significantly inhibited oxidative stress and prevented hepatocyte injury. Meanwhile one of the main active components of the Chinese medicine Curdione inhibited hepatic stellate cell activation by targeting the TGF-β1/Smads signaling pathway. The further in vivo experiments showed that Sin C, Curdione and the combination of both have the effect of reversing liver fibrosis in mice, and the combined effect of inhibiting hepatic fibrosis is superior to treatment with Sin C or Curdione alone. Our study provides a potential candidate for multi-molecular or multi-pathway combination therapies for the treatment of hepatic fibrosis and demonstrates that combined pharmacotherapy holds great promise in the prevention and treatment of hepatic fibrosis.Wenzhang DaiWenzhang DaiQin QinZhiyong LiLi LinRuisheng LiZhie FangYanzhong HanWenqing MuLutong RenTingting LiuXiaoyan ZhanXiaoyan ZhanXiaohe XiaoXiaohe XiaoXiaohe XiaoZhaofang BaiZhaofang BaiFrontiers Media S.A.articleschisandrin CCurdionehepatic fibrosisoxidative stressTGF-β1/Smads signaling pathwayBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	schisandrin C Curdione hepatic fibrosis oxidative stress TGF-β1/Smads signaling pathway Biology (General) QH301-705.5
spellingShingle	schisandrin C Curdione hepatic fibrosis oxidative stress TGF-β1/Smads signaling pathway Biology (General) QH301-705.5 Wenzhang Dai Wenzhang Dai Qin Qin Zhiyong Li Li Lin Ruisheng Li Zhie Fang Yanzhong Han Wenqing Mu Lutong Ren Tingting Liu Xiaoyan Zhan Xiaoyan Zhan Xiaohe Xiao Xiaohe Xiao Xiaohe Xiao Zhaofang Bai Zhaofang Bai Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress
description	Hepatic fibrosis is the final pathway of several chronic liver diseases, which is characterized by the accumulation of extracellular matrix due to chronic hepatocyte damage. Activation of hepatic stellate cells and oxidative stress (OS) play an important role in mediating liver damage and initiating hepatic fibrosis. Hence, hepatic fibrosis can be reversed by inhibiting multiple channels such as oxidative stress, liver cell damage, or activation of hepatic stellate cells. Liuwei Wuling Tablets is a traditional Chinese medicine formula with the effect of anti- hepatic fibrosis, but the composition and mechanism of reversing hepatic fibrosis are still unclear. Our study demonstrated that one of the main active components of the Chinese medicine Schisandra chinensis, schisandrin C (Sin C), significantly inhibited oxidative stress and prevented hepatocyte injury. Meanwhile one of the main active components of the Chinese medicine Curdione inhibited hepatic stellate cell activation by targeting the TGF-β1/Smads signaling pathway. The further in vivo experiments showed that Sin C, Curdione and the combination of both have the effect of reversing liver fibrosis in mice, and the combined effect of inhibiting hepatic fibrosis is superior to treatment with Sin C or Curdione alone. Our study provides a potential candidate for multi-molecular or multi-pathway combination therapies for the treatment of hepatic fibrosis and demonstrates that combined pharmacotherapy holds great promise in the prevention and treatment of hepatic fibrosis.
format	article
author	Wenzhang Dai Wenzhang Dai Qin Qin Zhiyong Li Li Lin Ruisheng Li Zhie Fang Yanzhong Han Wenqing Mu Lutong Ren Tingting Liu Xiaoyan Zhan Xiaoyan Zhan Xiaohe Xiao Xiaohe Xiao Xiaohe Xiao Zhaofang Bai Zhaofang Bai
author_facet	Wenzhang Dai Wenzhang Dai Qin Qin Zhiyong Li Li Lin Ruisheng Li Zhie Fang Yanzhong Han Wenqing Mu Lutong Ren Tingting Liu Xiaoyan Zhan Xiaoyan Zhan Xiaohe Xiao Xiaohe Xiao Xiaohe Xiao Zhaofang Bai Zhaofang Bai
author_sort	Wenzhang Dai
title	Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress
title_short	Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress
title_full	Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress
title_fullStr	Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress
title_full_unstemmed	Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress
title_sort	curdione and schisandrin c synergistically reverse hepatic fibrosis via modulating the tgf-β pathway and inhibiting oxidative stress
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a5e4b0dbbebf418cac2300267bcab8a7
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Curdione and Schisandrin C Synergistically Reverse Hepatic Fibrosis via Modulating the TGF-β Pathway and Inhibiting Oxidative Stress

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