Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins

Pentatricopeptide repeat proteins bind single-stranded RNA and have been used to study ssRNA biology. Here the authors co-opt these proteins to target ssDNA and demonstrate specific binding of telomere sequences, the structural basis for ssDNA wrapping, and use them as potent telomerase inhibitors.

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Autores principales:	Henrik Spåhr, Tiongsun Chia, James P. Lingford, Stefan J. Siira, Scott B. Cohen, Aleksandra Filipovska, Oliver Rackham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5f04e9e85b34966956baa59fefb1987
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spelling	oai:doaj.org-article:a5f04e9e85b34966956baa59fefb19872021-12-02T15:33:41ZModular ssDNA binding and inhibition of telomerase activity by designer PPR proteins10.1038/s41467-018-04388-12041-1723https://doaj.org/article/a5f04e9e85b34966956baa59fefb19872018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04388-1https://doaj.org/toc/2041-1723Pentatricopeptide repeat proteins bind single-stranded RNA and have been used to study ssRNA biology. Here the authors co-opt these proteins to target ssDNA and demonstrate specific binding of telomere sequences, the structural basis for ssDNA wrapping, and use them as potent telomerase inhibitors.Henrik SpåhrTiongsun ChiaJames P. LingfordStefan J. SiiraScott B. CohenAleksandra FilipovskaOliver RackhamNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Henrik Spåhr Tiongsun Chia James P. Lingford Stefan J. Siira Scott B. Cohen Aleksandra Filipovska Oliver Rackham Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins
description	Pentatricopeptide repeat proteins bind single-stranded RNA and have been used to study ssRNA biology. Here the authors co-opt these proteins to target ssDNA and demonstrate specific binding of telomere sequences, the structural basis for ssDNA wrapping, and use them as potent telomerase inhibitors.
format	article
author	Henrik Spåhr Tiongsun Chia James P. Lingford Stefan J. Siira Scott B. Cohen Aleksandra Filipovska Oliver Rackham
author_facet	Henrik Spåhr Tiongsun Chia James P. Lingford Stefan J. Siira Scott B. Cohen Aleksandra Filipovska Oliver Rackham
author_sort	Henrik Spåhr
title	Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins
title_short	Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins
title_full	Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins
title_fullStr	Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins
title_full_unstemmed	Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins
title_sort	modular ssdna binding and inhibition of telomerase activity by designer ppr proteins
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a5f04e9e85b34966956baa59fefb1987
work_keys_str_mv	AT henrikspahr modularssdnabindingandinhibitionoftelomeraseactivitybydesignerpprproteins AT tiongsunchia modularssdnabindingandinhibitionoftelomeraseactivitybydesignerpprproteins AT jamesplingford modularssdnabindingandinhibitionoftelomeraseactivitybydesignerpprproteins AT stefanjsiira modularssdnabindingandinhibitionoftelomeraseactivitybydesignerpprproteins AT scottbcohen modularssdnabindingandinhibitionoftelomeraseactivitybydesignerpprproteins AT aleksandrafilipovska modularssdnabindingandinhibitionoftelomeraseactivitybydesignerpprproteins AT oliverrackham modularssdnabindingandinhibitionoftelomeraseactivitybydesignerpprproteins
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Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins

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