ASK1 inhibits browning of white adipose tissue in obesity

Understanding the regulatory mechanisms governing brown and beige adipose mediated thermogenesis is of interest in order to develop therapeutic strategies to treat obesity. Here, the authors show that adipocyte-expressed apoptosis signal-regulating kinase 1 (ASK1) inhibits browning in response to co...

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Autores principales:	Fabrizio C. Lucchini, Stephan Wueest, Tenagne D. Challa, Flurin Item, Salvatore Modica, Marcela Borsigova, Yulia Haim, Christian Wolfrum, Assaf Rudich, Daniel Konrad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5f0fcf02ab1420cbe65f5ab4e73cc5e
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spelling	oai:doaj.org-article:a5f0fcf02ab1420cbe65f5ab4e73cc5e2021-12-02T14:40:51ZASK1 inhibits browning of white adipose tissue in obesity10.1038/s41467-020-15483-72041-1723https://doaj.org/article/a5f0fcf02ab1420cbe65f5ab4e73cc5e2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15483-7https://doaj.org/toc/2041-1723Understanding the regulatory mechanisms governing brown and beige adipose mediated thermogenesis is of interest in order to develop therapeutic strategies to treat obesity. Here, the authors show that adipocyte-expressed apoptosis signal-regulating kinase 1 (ASK1) inhibits browning in response to cold, β3 receptor activation, and LPS.Fabrizio C. LucchiniStephan WueestTenagne D. ChallaFlurin ItemSalvatore ModicaMarcela BorsigovaYulia HaimChristian WolfrumAssaf RudichDaniel KonradNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabrizio C. Lucchini Stephan Wueest Tenagne D. Challa Flurin Item Salvatore Modica Marcela Borsigova Yulia Haim Christian Wolfrum Assaf Rudich Daniel Konrad ASK1 inhibits browning of white adipose tissue in obesity
description	Understanding the regulatory mechanisms governing brown and beige adipose mediated thermogenesis is of interest in order to develop therapeutic strategies to treat obesity. Here, the authors show that adipocyte-expressed apoptosis signal-regulating kinase 1 (ASK1) inhibits browning in response to cold, β3 receptor activation, and LPS.
format	article
author	Fabrizio C. Lucchini Stephan Wueest Tenagne D. Challa Flurin Item Salvatore Modica Marcela Borsigova Yulia Haim Christian Wolfrum Assaf Rudich Daniel Konrad
author_facet	Fabrizio C. Lucchini Stephan Wueest Tenagne D. Challa Flurin Item Salvatore Modica Marcela Borsigova Yulia Haim Christian Wolfrum Assaf Rudich Daniel Konrad
author_sort	Fabrizio C. Lucchini
title	ASK1 inhibits browning of white adipose tissue in obesity
title_short	ASK1 inhibits browning of white adipose tissue in obesity
title_full	ASK1 inhibits browning of white adipose tissue in obesity
title_fullStr	ASK1 inhibits browning of white adipose tissue in obesity
title_full_unstemmed	ASK1 inhibits browning of white adipose tissue in obesity
title_sort	ask1 inhibits browning of white adipose tissue in obesity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a5f0fcf02ab1420cbe65f5ab4e73cc5e
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ASK1 inhibits browning of white adipose tissue in obesity

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