The germline genetic component of drug sensitivity in cancer cell lines

Little is known about the contribution of germline genetic variants to cancer drug sensitivity. Here, the authors devise an approach for joint analysis of germline variants and somatic mutations, identifying substantial germline contributions to variation in drug sensitivity.

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Autores principales:	Michael P. Menden, Francesco Paolo Casale, Johannes Stephan, Graham R. Bignell, Francesco Iorio, Ultan McDermott, Mathew J. Garnett, Julio Saez-Rodriguez, Oliver Stegle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a5f22af9ae8a4bdfa6b0d4bf920d0315
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spelling	oai:doaj.org-article:a5f22af9ae8a4bdfa6b0d4bf920d03152021-12-02T15:33:57ZThe germline genetic component of drug sensitivity in cancer cell lines10.1038/s41467-018-05811-32041-1723https://doaj.org/article/a5f22af9ae8a4bdfa6b0d4bf920d03152018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05811-3https://doaj.org/toc/2041-1723Little is known about the contribution of germline genetic variants to cancer drug sensitivity. Here, the authors devise an approach for joint analysis of germline variants and somatic mutations, identifying substantial germline contributions to variation in drug sensitivity.Michael P. MendenFrancesco Paolo CasaleJohannes StephanGraham R. BignellFrancesco IorioUltan McDermottMathew J. GarnettJulio Saez-RodriguezOliver StegleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael P. Menden Francesco Paolo Casale Johannes Stephan Graham R. Bignell Francesco Iorio Ultan McDermott Mathew J. Garnett Julio Saez-Rodriguez Oliver Stegle The germline genetic component of drug sensitivity in cancer cell lines
description	Little is known about the contribution of germline genetic variants to cancer drug sensitivity. Here, the authors devise an approach for joint analysis of germline variants and somatic mutations, identifying substantial germline contributions to variation in drug sensitivity.
format	article
author	Michael P. Menden Francesco Paolo Casale Johannes Stephan Graham R. Bignell Francesco Iorio Ultan McDermott Mathew J. Garnett Julio Saez-Rodriguez Oliver Stegle
author_facet	Michael P. Menden Francesco Paolo Casale Johannes Stephan Graham R. Bignell Francesco Iorio Ultan McDermott Mathew J. Garnett Julio Saez-Rodriguez Oliver Stegle
author_sort	Michael P. Menden
title	The germline genetic component of drug sensitivity in cancer cell lines
title_short	The germline genetic component of drug sensitivity in cancer cell lines
title_full	The germline genetic component of drug sensitivity in cancer cell lines
title_fullStr	The germline genetic component of drug sensitivity in cancer cell lines
title_full_unstemmed	The germline genetic component of drug sensitivity in cancer cell lines
title_sort	germline genetic component of drug sensitivity in cancer cell lines
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a5f22af9ae8a4bdfa6b0d4bf920d0315
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The germline genetic component of drug sensitivity in cancer cell lines

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