Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea

Abstract Mature mammalian cochlear hair cells (HCs) do not spontaneously regenerate once lost, leading to life-long hearing deficits. Attempts to induce HC regeneration in adult mammals have used over-expression of the HC-specific transcription factor Atoh1, but to date this approach has yielded low...

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Autores principales: Sungsu Lee, Jae-Jun Song, Lisa A. Beyer, Donald L. Swiderski, Diane M. Prieskorn, Melih Acar, Hsin-I Jen, Andrew K. Groves, Yehoash Raphael
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/a5f302ca620148b1ae8d55867529301b
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