A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma

A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma

Super enhancers are frequently involved in the dysregulation of gene expression in cancer. Here, in kidney cancer, a super enhancer is shown to drive the expression of KLF6, which alters the expression of lipid metabolism genes and promotes tumorigenesis.

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Autores principales: Saiful E. Syafruddin, Paulo Rodrigues, Erika Vojtasova, Saroor A. Patel, M. Nazhif Zaini, Johanna Burge, Anne Y. Warren, Grant D. Stewart, Tim Eisen, Dóra Bihary, Shamith A. Samarajiwa, Sakari Vanharanta
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/a5f554ded6384cebbff78912728a65e7
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spelling oai:doaj.org-article:a5f554ded6384cebbff78912728a65e72021-12-02T17:01:57ZA KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma10.1038/s41467-019-09116-x2041-1723https://doaj.org/article/a5f554ded6384cebbff78912728a65e72019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09116-xhttps://doaj.org/toc/2041-1723Super enhancers are frequently involved in the dysregulation of gene expression in cancer. Here, in kidney cancer, a super enhancer is shown to drive the expression of KLF6, which alters the expression of lipid metabolism genes and promotes tumorigenesis.Saiful E. SyafruddinPaulo RodriguesErika VojtasovaSaroor A. PatelM. Nazhif ZainiJohanna BurgeAnne Y. WarrenGrant D. StewartTim EisenDóra BiharyShamith A. SamarajiwaSakari VanharantaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Saiful E. Syafruddin
Paulo Rodrigues
Erika Vojtasova
Saroor A. Patel
M. Nazhif Zaini
Johanna Burge
Anne Y. Warren
Grant D. Stewart
Tim Eisen
Dóra Bihary
Shamith A. Samarajiwa
Sakari Vanharanta
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma
description Super enhancers are frequently involved in the dysregulation of gene expression in cancer. Here, in kidney cancer, a super enhancer is shown to drive the expression of KLF6, which alters the expression of lipid metabolism genes and promotes tumorigenesis.
format article
author Saiful E. Syafruddin
Paulo Rodrigues
Erika Vojtasova
Saroor A. Patel
M. Nazhif Zaini
Johanna Burge
Anne Y. Warren
Grant D. Stewart
Tim Eisen
Dóra Bihary
Shamith A. Samarajiwa
Sakari Vanharanta
author_facet Saiful E. Syafruddin
Paulo Rodrigues
Erika Vojtasova
Saroor A. Patel
M. Nazhif Zaini
Johanna Burge
Anne Y. Warren
Grant D. Stewart
Tim Eisen
Dóra Bihary
Shamith A. Samarajiwa
Sakari Vanharanta
author_sort Saiful E. Syafruddin
title A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma
title_short A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma
title_full A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma
title_fullStr A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma
title_full_unstemmed A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma
title_sort klf6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/a5f554ded6384cebbff78912728a65e7
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