Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma

The aim of this study was to investigate the changes in circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during the course of chemoradiation in patients with cervical cancer. Sixteen patients with histologically confirmed carcinoma of the uterine cervix, aged 53 ± 15 y...

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Autores principales:	Pospíšková Markéta, Strouhal Ondřej, Hlídková Eva, Vlachová Zuzana, Melichar Bohuslav, Doležel Martin
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	cervical carcinoma chemoradiation citrulline kynurenine neopterin tryptophan Crystallography QD901-999
Acceso en línea:	https://doaj.org/article/a5f58a5cd4334fecaee98469f73846c4
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spelling	oai:doaj.org-article:a5f58a5cd4334fecaee98469f73846c42021-12-05T14:11:02ZCirculating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma2195-472010.1515/pteridines-2020-0032https://doaj.org/article/a5f58a5cd4334fecaee98469f73846c42021-11-01T00:00:00Zhttps://doi.org/10.1515/pteridines-2020-0032https://doaj.org/toc/2195-4720The aim of this study was to investigate the changes in circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during the course of chemoradiation in patients with cervical cancer. Sixteen patients with histologically confirmed carcinoma of the uterine cervix, aged 53 ± 15 years (range 29–76 years), were included in this study. Plasma neopterin, kynurenine, and tryptophan were determined with an enzyme-linked immunosorbent assay. Plasma citrulline was measured with high-performance liquid chromatography. Compared to baseline, citrulline concentration was markedly and statistically significantly decreased at visits 2, 3, and 4, while returning to pretreatment concentrations at visit 5. A significant increase in serum neopterin concentrations was observed at visits 4 and 5. With the exception of decreased kynurenine/tryptophan ratio at visit 3, no significant changes were observed in the concentrations of kynurenine, tryptophan, and kynurenine/tryptophan ratio throughout the course of the treatment. In conclusion, present data demonstrate that citrulline concentrations decrease early and neopterin concentrations increase late during the course of chemoradiation in patients with cervical carcinoma. Citrulline represents a biomarker of intestinal toxicity in this population.Pospíšková MarkétaStrouhal OndřejHlídková EvaVlachová ZuzanaMelichar BohuslavDoležel MartinDe Gruyterarticlecervical carcinomachemoradiationcitrullinekynurenineneopterintryptophanCrystallographyQD901-999ENPteridines, Vol 32, Iss 1, Pp 93-97 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cervical carcinoma chemoradiation citrulline kynurenine neopterin tryptophan Crystallography QD901-999
spellingShingle	cervical carcinoma chemoradiation citrulline kynurenine neopterin tryptophan Crystallography QD901-999 Pospíšková Markéta Strouhal Ondřej Hlídková Eva Vlachová Zuzana Melichar Bohuslav Doležel Martin Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma
description	The aim of this study was to investigate the changes in circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during the course of chemoradiation in patients with cervical cancer. Sixteen patients with histologically confirmed carcinoma of the uterine cervix, aged 53 ± 15 years (range 29–76 years), were included in this study. Plasma neopterin, kynurenine, and tryptophan were determined with an enzyme-linked immunosorbent assay. Plasma citrulline was measured with high-performance liquid chromatography. Compared to baseline, citrulline concentration was markedly and statistically significantly decreased at visits 2, 3, and 4, while returning to pretreatment concentrations at visit 5. A significant increase in serum neopterin concentrations was observed at visits 4 and 5. With the exception of decreased kynurenine/tryptophan ratio at visit 3, no significant changes were observed in the concentrations of kynurenine, tryptophan, and kynurenine/tryptophan ratio throughout the course of the treatment. In conclusion, present data demonstrate that citrulline concentrations decrease early and neopterin concentrations increase late during the course of chemoradiation in patients with cervical carcinoma. Citrulline represents a biomarker of intestinal toxicity in this population.
format	article
author	Pospíšková Markéta Strouhal Ondřej Hlídková Eva Vlachová Zuzana Melichar Bohuslav Doležel Martin
author_facet	Pospíšková Markéta Strouhal Ondřej Hlídková Eva Vlachová Zuzana Melichar Bohuslav Doležel Martin
author_sort	Pospíšková Markéta
title	Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma
title_short	Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma
title_full	Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma
title_fullStr	Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma
title_full_unstemmed	Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma
title_sort	circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/a5f58a5cd4334fecaee98469f73846c4
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Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma

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