An update on the toxicity of Aβ in Alzheimer’s disease
Jürgen Götz1, Lars M Ittner1, Nicole Schonrock1, Roberto Cappai21Alzheimer’s and Parkinson’s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, NSW, Australia; 2Department of Pathology, The University of Melbourne, Victo...
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Dove Medical Press
2008
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oai:doaj.org-article:a5f855e5836944cf9e7885f9fdbf91702021-12-02T03:42:05ZAn update on the toxicity of Aβ in Alzheimer’s disease1176-63281178-2021https://doaj.org/article/a5f855e5836944cf9e7885f9fdbf91702008-12-01T00:00:00Zhttp://www.dovepress.com/an-update-on-the-toxicity-of-abeta-in-alzheimerrsquos-disease-a2710https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Jürgen Götz1, Lars M Ittner1, Nicole Schonrock1, Roberto Cappai21Alzheimer’s and Parkinson’s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, NSW, Australia; 2Department of Pathology, The University of Melbourne, Victoria, AustraliaAbstract: Alzheimer’s disease is characterized histopathologically by deposition of insoluble forms of the peptide Aβ and the protein tau in brain. Aβ is the principal component of amyloid plaques and tau of neurofibrillary tangles. Familial cases of AD are associated with causal mutations in the gene encoding the amyloid precursor protein, APP, from which the amyloidogenic Aβ peptide is derived, and this supports a role for Aβ in disease. Aβ can promote tau pathology and at the same time its toxicity is also tau-dependent. Aβ can adopt different conformations including soluble oligomers and insoluble fibrillar species present in plaques. We discuss which of these conformations exert toxicity, highlight molecular pathways involved and discuss what has been learned by applying functional genomics.Keywords: amyloid, mitochondria, oligomer, proteomic, tau, transgenic Jürgen GötzLars M IttnerNicole SchonrockRoberto CappaiDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 6, Pp 1033-1042 (2008) |
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DOAJ |
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EN |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jürgen Götz Lars M Ittner Nicole Schonrock Roberto Cappai An update on the toxicity of Aβ in Alzheimer’s disease |
| description |
Jürgen Götz1, Lars M Ittner1, Nicole Schonrock1, Roberto Cappai21Alzheimer’s and Parkinson’s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, NSW, Australia; 2Department of Pathology, The University of Melbourne, Victoria, AustraliaAbstract: Alzheimer’s disease is characterized histopathologically by deposition of insoluble forms of the peptide Aβ and the protein tau in brain. Aβ is the principal component of amyloid plaques and tau of neurofibrillary tangles. Familial cases of AD are associated with causal mutations in the gene encoding the amyloid precursor protein, APP, from which the amyloidogenic Aβ peptide is derived, and this supports a role for Aβ in disease. Aβ can promote tau pathology and at the same time its toxicity is also tau-dependent. Aβ can adopt different conformations including soluble oligomers and insoluble fibrillar species present in plaques. We discuss which of these conformations exert toxicity, highlight molecular pathways involved and discuss what has been learned by applying functional genomics.Keywords: amyloid, mitochondria, oligomer, proteomic, tau, transgenic |
| format |
article |
| author |
Jürgen Götz Lars M Ittner Nicole Schonrock Roberto Cappai |
| author_facet |
Jürgen Götz Lars M Ittner Nicole Schonrock Roberto Cappai |
| author_sort |
Jürgen Götz |
| title |
An update on the toxicity of Aβ in Alzheimer’s disease |
| title_short |
An update on the toxicity of Aβ in Alzheimer’s disease |
| title_full |
An update on the toxicity of Aβ in Alzheimer’s disease |
| title_fullStr |
An update on the toxicity of Aβ in Alzheimer’s disease |
| title_full_unstemmed |
An update on the toxicity of Aβ in Alzheimer’s disease |
| title_sort |
update on the toxicity of aβ in alzheimer’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/a5f855e5836944cf9e7885f9fdbf9170 |
| work_keys_str_mv |
AT jampuumlrgengampoumltz anupdateonthetoxicityofaampbetainalzheimeramprsquosdisease AT larsmittner anupdateonthetoxicityofaampbetainalzheimeramprsquosdisease AT nicoleschonrock anupdateonthetoxicityofaampbetainalzheimeramprsquosdisease AT robertocappai anupdateonthetoxicityofaampbetainalzheimeramprsquosdisease AT jampuumlrgengampoumltz updateonthetoxicityofaampbetainalzheimeramprsquosdisease AT larsmittner updateonthetoxicityofaampbetainalzheimeramprsquosdisease AT nicoleschonrock updateonthetoxicityofaampbetainalzheimeramprsquosdisease AT robertocappai updateonthetoxicityofaampbetainalzheimeramprsquosdisease |
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1718401688548671488 |