Mechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a malignancy with high heterogeneity in its biological features and treatments. Although the overall survival (OS) of patients with ALL has recently improved considerably, owing to the application of conventional chemo-therapeutic agents, approximately 20% of th...

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Autores principales:	Silvia Jiménez-Morales, Ivan Sammir Aranda-Uribe, Carlos Jhovani Pérez-Amado, Julian Ramírez-Bello, Alfredo Hidalgo-Miranda
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	acute lymphoblastic leukemia immunoediting immunotherapy tumor immune evasion immune cells Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a5fa3f0c953e4009bd4659fe726e9991
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spelling	oai:doaj.org-article:a5fa3f0c953e4009bd4659fe726e99912021-11-18T05:18:47ZMechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia1664-322410.3389/fimmu.2021.737340https://doaj.org/article/a5fa3f0c953e4009bd4659fe726e99912021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.737340/fullhttps://doaj.org/toc/1664-3224Acute lymphoblastic leukemia (ALL) is a malignancy with high heterogeneity in its biological features and treatments. Although the overall survival (OS) of patients with ALL has recently improved considerably, owing to the application of conventional chemo-therapeutic agents, approximately 20% of the pediatric cases and 40–50% of the adult patients relapse during and after the treatment period. The potential mechanisms that cause relapse involve clonal evolution, innate and acquired chemoresistance, and the ability of ALL cells to escape the immune-suppressive tumor response. Currently, immunotherapy in combination with conventional treatment is used to enhance the immune response against tumor cells, thereby significantly improving the OS in patients with ALL. Therefore, understanding the mechanisms of immune evasion by leukemia cells could be useful for developing novel therapeutic strategies.Silvia Jiménez-MoralesIvan Sammir Aranda-UribeIvan Sammir Aranda-UribeCarlos Jhovani Pérez-AmadoCarlos Jhovani Pérez-AmadoJulian Ramírez-BelloAlfredo Hidalgo-MirandaFrontiers Media S.A.articleacute lymphoblastic leukemiaimmunoeditingimmunotherapytumor immune evasionimmune cellsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute lymphoblastic leukemia immunoediting immunotherapy tumor immune evasion immune cells Immunologic diseases. Allergy RC581-607
spellingShingle	acute lymphoblastic leukemia immunoediting immunotherapy tumor immune evasion immune cells Immunologic diseases. Allergy RC581-607 Silvia Jiménez-Morales Ivan Sammir Aranda-Uribe Ivan Sammir Aranda-Uribe Carlos Jhovani Pérez-Amado Carlos Jhovani Pérez-Amado Julian Ramírez-Bello Alfredo Hidalgo-Miranda Mechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia
description	Acute lymphoblastic leukemia (ALL) is a malignancy with high heterogeneity in its biological features and treatments. Although the overall survival (OS) of patients with ALL has recently improved considerably, owing to the application of conventional chemo-therapeutic agents, approximately 20% of the pediatric cases and 40–50% of the adult patients relapse during and after the treatment period. The potential mechanisms that cause relapse involve clonal evolution, innate and acquired chemoresistance, and the ability of ALL cells to escape the immune-suppressive tumor response. Currently, immunotherapy in combination with conventional treatment is used to enhance the immune response against tumor cells, thereby significantly improving the OS in patients with ALL. Therefore, understanding the mechanisms of immune evasion by leukemia cells could be useful for developing novel therapeutic strategies.
format	article
author	Silvia Jiménez-Morales Ivan Sammir Aranda-Uribe Ivan Sammir Aranda-Uribe Carlos Jhovani Pérez-Amado Carlos Jhovani Pérez-Amado Julian Ramírez-Bello Alfredo Hidalgo-Miranda
author_facet	Silvia Jiménez-Morales Ivan Sammir Aranda-Uribe Ivan Sammir Aranda-Uribe Carlos Jhovani Pérez-Amado Carlos Jhovani Pérez-Amado Julian Ramírez-Bello Alfredo Hidalgo-Miranda
author_sort	Silvia Jiménez-Morales
title	Mechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia
title_short	Mechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia
title_full	Mechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia
title_fullStr	Mechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia
title_full_unstemmed	Mechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia
title_sort	mechanisms of immunosuppressive tumor evasion: focus on acute lymphoblastic leukemia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a5fa3f0c953e4009bd4659fe726e9991
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Mechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia

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