Flow-induced elongation of von Willebrand factor precedes tension-dependent activation

Von Willebrand factor (VWF) is a blood protein involved in clotting and is proposed to be activated by flow, but the mechanism is unknown. Here the authors show that VWF is first converted from a compact to linear form by flow, and is subsequently activated to bind GPIbα in a tension-dependent manne...

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Main Authors:	Hongxia Fu, Yan Jiang, Darren Yang, Friedrich Scheiflinger, Wesley P. Wong, Timothy A. Springer
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/a5fbfb5781ac4911a873b2e2e5610c15
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spelling	oai:doaj.org-article:a5fbfb5781ac4911a873b2e2e5610c152021-12-02T13:57:55ZFlow-induced elongation of von Willebrand factor precedes tension-dependent activation10.1038/s41467-017-00230-22041-1723https://doaj.org/article/a5fbfb5781ac4911a873b2e2e5610c152017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00230-2https://doaj.org/toc/2041-1723Von Willebrand factor (VWF) is a blood protein involved in clotting and is proposed to be activated by flow, but the mechanism is unknown. Here the authors show that VWF is first converted from a compact to linear form by flow, and is subsequently activated to bind GPIbα in a tension-dependent manner.Hongxia FuYan JiangDarren YangFriedrich ScheiflingerWesley P. WongTimothy A. SpringerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongxia Fu Yan Jiang Darren Yang Friedrich Scheiflinger Wesley P. Wong Timothy A. Springer Flow-induced elongation of von Willebrand factor precedes tension-dependent activation
description	Von Willebrand factor (VWF) is a blood protein involved in clotting and is proposed to be activated by flow, but the mechanism is unknown. Here the authors show that VWF is first converted from a compact to linear form by flow, and is subsequently activated to bind GPIbα in a tension-dependent manner.
format	article
author	Hongxia Fu Yan Jiang Darren Yang Friedrich Scheiflinger Wesley P. Wong Timothy A. Springer
author_facet	Hongxia Fu Yan Jiang Darren Yang Friedrich Scheiflinger Wesley P. Wong Timothy A. Springer
author_sort	Hongxia Fu
title	Flow-induced elongation of von Willebrand factor precedes tension-dependent activation
title_short	Flow-induced elongation of von Willebrand factor precedes tension-dependent activation
title_full	Flow-induced elongation of von Willebrand factor precedes tension-dependent activation
title_fullStr	Flow-induced elongation of von Willebrand factor precedes tension-dependent activation
title_full_unstemmed	Flow-induced elongation of von Willebrand factor precedes tension-dependent activation
title_sort	flow-induced elongation of von willebrand factor precedes tension-dependent activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a5fbfb5781ac4911a873b2e2e5610c15
work_keys_str_mv	AT hongxiafu flowinducedelongationofvonwillebrandfactorprecedestensiondependentactivation AT yanjiang flowinducedelongationofvonwillebrandfactorprecedestensiondependentactivation AT darrenyang flowinducedelongationofvonwillebrandfactorprecedestensiondependentactivation AT friedrichscheiflinger flowinducedelongationofvonwillebrandfactorprecedestensiondependentactivation AT wesleypwong flowinducedelongationofvonwillebrandfactorprecedestensiondependentactivation AT timothyaspringer flowinducedelongationofvonwillebrandfactorprecedestensiondependentactivation
_version_	1718392278741942272

Flow-induced elongation of von Willebrand factor precedes tension-dependent activation

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