Metallothionein 1: A New Spotlight on Inflammatory Diseases

MT1 has been demonstrated to be an essential stress protein in maintaining physiological balance and regulating immune homeostasis. While the immunological involvement of MT1 in central nervous system disorders and cancer has been extensively investigated, mounting evidence suggests that MT1 has a b...

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Autores principales:	Hanying Dai, Lu Wang, Lingyun Li, Zhong Huang, Liang Ye
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	metallothionein 1 inflammatory disease signaling metal cytokine immunoregulation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a5fe11d89f11480d8346eb1cfa72df2b
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spelling	oai:doaj.org-article:a5fe11d89f11480d8346eb1cfa72df2b2021-11-05T10:14:26ZMetallothionein 1: A New Spotlight on Inflammatory Diseases1664-322410.3389/fimmu.2021.739918https://doaj.org/article/a5fe11d89f11480d8346eb1cfa72df2b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.739918/fullhttps://doaj.org/toc/1664-3224MT1 has been demonstrated to be an essential stress protein in maintaining physiological balance and regulating immune homeostasis. While the immunological involvement of MT1 in central nervous system disorders and cancer has been extensively investigated, mounting evidence suggests that MT1 has a broader role in inflammatory diseases and can shape innate and adaptive immunity. In this review, we will first summarize the biological features of MT1 and the regulators that influence MT1 expression, emphasizing metal, inflammation, and immunosuppressive factors. We will then focus on the immunoregulatory function of MT1 on diverse immune cells and the signaling pathways regulated by MT1. Finally, we will discuss recent advances in our knowledge of the biological role of MT1 in several inflammatory diseases to develop novel therapeutic strategies.Hanying DaiLu WangLingyun LiZhong HuangLiang YeFrontiers Media S.A.articlemetallothionein 1inflammatory diseasesignalingmetalcytokineimmunoregulationImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metallothionein 1 inflammatory disease signaling metal cytokine immunoregulation Immunologic diseases. Allergy RC581-607
spellingShingle	metallothionein 1 inflammatory disease signaling metal cytokine immunoregulation Immunologic diseases. Allergy RC581-607 Hanying Dai Lu Wang Lingyun Li Zhong Huang Liang Ye Metallothionein 1: A New Spotlight on Inflammatory Diseases
description	MT1 has been demonstrated to be an essential stress protein in maintaining physiological balance and regulating immune homeostasis. While the immunological involvement of MT1 in central nervous system disorders and cancer has been extensively investigated, mounting evidence suggests that MT1 has a broader role in inflammatory diseases and can shape innate and adaptive immunity. In this review, we will first summarize the biological features of MT1 and the regulators that influence MT1 expression, emphasizing metal, inflammation, and immunosuppressive factors. We will then focus on the immunoregulatory function of MT1 on diverse immune cells and the signaling pathways regulated by MT1. Finally, we will discuss recent advances in our knowledge of the biological role of MT1 in several inflammatory diseases to develop novel therapeutic strategies.
format	article
author	Hanying Dai Lu Wang Lingyun Li Zhong Huang Liang Ye
author_facet	Hanying Dai Lu Wang Lingyun Li Zhong Huang Liang Ye
author_sort	Hanying Dai
title	Metallothionein 1: A New Spotlight on Inflammatory Diseases
title_short	Metallothionein 1: A New Spotlight on Inflammatory Diseases
title_full	Metallothionein 1: A New Spotlight on Inflammatory Diseases
title_fullStr	Metallothionein 1: A New Spotlight on Inflammatory Diseases
title_full_unstemmed	Metallothionein 1: A New Spotlight on Inflammatory Diseases
title_sort	metallothionein 1: a new spotlight on inflammatory diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a5fe11d89f11480d8346eb1cfa72df2b
work_keys_str_mv	AT hanyingdai metallothionein1anewspotlightoninflammatorydiseases AT luwang metallothionein1anewspotlightoninflammatorydiseases AT lingyunli metallothionein1anewspotlightoninflammatorydiseases AT zhonghuang metallothionein1anewspotlightoninflammatorydiseases AT liangye metallothionein1anewspotlightoninflammatorydiseases
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Metallothionein 1: A New Spotlight on Inflammatory Diseases

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