Primary vitreoretinal lymphoma: prevalence, impact, and management challenges

Ramesh Venkatesh,1 Bharathi Bavaharan,1 Padmamalini Mahendradas,2 Naresh Kumar Yadav1 1Department of Retina and Vitreous, Narayana Nethralaya, Bengaluru – 560010, India; 2Department of Uvea and Intraocular Inflammation, Narayana Nethralaya, Bengaluru – 560010, India Abstract: P...

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Autores principales:	Venkatesh R, Bavaharan B, Mahendradas P, Yadav NK
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	primary vitreoretinal lymphoma chemotherapy intraocular lymphomas Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a601312f64e1409b96d170883ecea710
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spelling	oai:doaj.org-article:a601312f64e1409b96d170883ecea7102021-12-02T05:05:46ZPrimary vitreoretinal lymphoma: prevalence, impact, and management challenges1177-5483https://doaj.org/article/a601312f64e1409b96d170883ecea7102019-02-01T00:00:00Zhttps://www.dovepress.com/primary-vitreoretinal-lymphoma-prevalence-impact-and-management-challe-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Ramesh Venkatesh,1 Bharathi Bavaharan,1 Padmamalini Mahendradas,2 Naresh Kumar Yadav1 1Department of Retina and Vitreous, Narayana Nethralaya, Bengaluru – 560010, India; 2Department of Uvea and Intraocular Inflammation, Narayana Nethralaya, Bengaluru – 560010, India Abstract: Primary vitreoretinal lymphoma (PVRL) is a rare and potentially fatal intraocular malignancy. More than half of PVRL cases eventually involve the central nervous system (CNS). PVRL frequently masquerades as chronic uveitis. Advanced imaging tests, such as optical coherence tomography and fundus autofluorescence, have been applied in the diagnosis of PVRL. Histology and immunohistochemistry, in combination with molecular tests and IL-10 analysis, have been demonstrated as reliable in diagnosing PVRL. Mortality is high in patients with PVRL associated with CNS involvement, and relapses are common. The use of systemic chemotherapy in addition to the local therapies has proved to extend the mean survival time of these patients. Local therapies, including intravitreal injections of methotrexate and/or rituximab and low-dose radiotherapy to the eye, have been shown to be extremely effective in controlling intraocular lymphoma. Keywords: CNS lymphoma, malignancy, ocular tumor, treatment, investigations, prognosisVenkatesh RBavaharan BMahendradas PYadav NKDove Medical Pressarticleprimary vitreoretinal lymphomachemotherapyintraocular lymphomasOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 353-364 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	primary vitreoretinal lymphoma chemotherapy intraocular lymphomas Ophthalmology RE1-994
spellingShingle	primary vitreoretinal lymphoma chemotherapy intraocular lymphomas Ophthalmology RE1-994 Venkatesh R Bavaharan B Mahendradas P Yadav NK Primary vitreoretinal lymphoma: prevalence, impact, and management challenges
description	Ramesh Venkatesh,1 Bharathi Bavaharan,1 Padmamalini Mahendradas,2 Naresh Kumar Yadav1 1Department of Retina and Vitreous, Narayana Nethralaya, Bengaluru – 560010, India; 2Department of Uvea and Intraocular Inflammation, Narayana Nethralaya, Bengaluru – 560010, India Abstract: Primary vitreoretinal lymphoma (PVRL) is a rare and potentially fatal intraocular malignancy. More than half of PVRL cases eventually involve the central nervous system (CNS). PVRL frequently masquerades as chronic uveitis. Advanced imaging tests, such as optical coherence tomography and fundus autofluorescence, have been applied in the diagnosis of PVRL. Histology and immunohistochemistry, in combination with molecular tests and IL-10 analysis, have been demonstrated as reliable in diagnosing PVRL. Mortality is high in patients with PVRL associated with CNS involvement, and relapses are common. The use of systemic chemotherapy in addition to the local therapies has proved to extend the mean survival time of these patients. Local therapies, including intravitreal injections of methotrexate and/or rituximab and low-dose radiotherapy to the eye, have been shown to be extremely effective in controlling intraocular lymphoma. Keywords: CNS lymphoma, malignancy, ocular tumor, treatment, investigations, prognosis
format	article
author	Venkatesh R Bavaharan B Mahendradas P Yadav NK
author_facet	Venkatesh R Bavaharan B Mahendradas P Yadav NK
author_sort	Venkatesh R
title	Primary vitreoretinal lymphoma: prevalence, impact, and management challenges
title_short	Primary vitreoretinal lymphoma: prevalence, impact, and management challenges
title_full	Primary vitreoretinal lymphoma: prevalence, impact, and management challenges
title_fullStr	Primary vitreoretinal lymphoma: prevalence, impact, and management challenges
title_full_unstemmed	Primary vitreoretinal lymphoma: prevalence, impact, and management challenges
title_sort	primary vitreoretinal lymphoma: prevalence, impact, and management challenges
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/a601312f64e1409b96d170883ecea710
work_keys_str_mv	AT venkateshr primaryvitreoretinallymphomaprevalenceimpactandmanagementchallenges AT bavaharanb primaryvitreoretinallymphomaprevalenceimpactandmanagementchallenges AT mahendradasp primaryvitreoretinallymphomaprevalenceimpactandmanagementchallenges AT yadavnk primaryvitreoretinallymphomaprevalenceimpactandmanagementchallenges
_version_	1718400612822941696

Primary vitreoretinal lymphoma: prevalence, impact, and management challenges

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