Spontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons.

In rodents, the infralimbic (IL) region of the medial prefrontal cortex plays a key role in the recall of fear extinction. Previously we showed that fear conditioning decreases the intrinsic excitability of IL neurons, and that fear extinction reverses the depressed excitability. In the current stud...

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Autores principales:	Emmanuel Cruz, Ana V López, James T Porter
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a60993a4b8004e7fb0c1e10f31634f48
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spelling	oai:doaj.org-article:a60993a4b8004e7fb0c1e10f31634f482021-11-25T06:06:06ZSpontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons.1932-620310.1371/journal.pone.0103596https://doaj.org/article/a60993a4b8004e7fb0c1e10f31634f482014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25089624/?tool=EBIhttps://doaj.org/toc/1932-6203In rodents, the infralimbic (IL) region of the medial prefrontal cortex plays a key role in the recall of fear extinction. Previously we showed that fear conditioning decreases the intrinsic excitability of IL neurons, and that fear extinction reverses the depressed excitability. In the current study, we examined the time course of the extinction-induced changes in adolescent rats. Immediately after extinction, IL neurons continued to show depressed excitability. However 4 hours after extinction, IL neurons showed an increase in evoked spikes that correlated with a reduced fast afterhyperpolarizing potential. This suggests that acquisition of fear extinction induces an increase in spike firing 4 hours later, during the consolidation of extinction. We also examined IL excitability in a group of rats that showed spontaneous recovery of fear 17 days after extinction (SR group). Similar to neurons after fear conditioning, IL neurons from the SR group showed depressed intrinsic excitability compared to neurons 4 hours after extinction, suggesting that extinction-induced enhancement in intrinsic excitability decreases with time reverting back to a depressed state. These results suggest that plasticity in IL contributes to the spontaneous recovery of fear and preventing this depression of IL excitability could prolong fear extinction.Emmanuel CruzAna V LópezJames T PorterPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e103596 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emmanuel Cruz Ana V López James T Porter Spontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons.
description	In rodents, the infralimbic (IL) region of the medial prefrontal cortex plays a key role in the recall of fear extinction. Previously we showed that fear conditioning decreases the intrinsic excitability of IL neurons, and that fear extinction reverses the depressed excitability. In the current study, we examined the time course of the extinction-induced changes in adolescent rats. Immediately after extinction, IL neurons continued to show depressed excitability. However 4 hours after extinction, IL neurons showed an increase in evoked spikes that correlated with a reduced fast afterhyperpolarizing potential. This suggests that acquisition of fear extinction induces an increase in spike firing 4 hours later, during the consolidation of extinction. We also examined IL excitability in a group of rats that showed spontaneous recovery of fear 17 days after extinction (SR group). Similar to neurons after fear conditioning, IL neurons from the SR group showed depressed intrinsic excitability compared to neurons 4 hours after extinction, suggesting that extinction-induced enhancement in intrinsic excitability decreases with time reverting back to a depressed state. These results suggest that plasticity in IL contributes to the spontaneous recovery of fear and preventing this depression of IL excitability could prolong fear extinction.
format	article
author	Emmanuel Cruz Ana V López James T Porter
author_facet	Emmanuel Cruz Ana V López James T Porter
author_sort	Emmanuel Cruz
title	Spontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons.
title_short	Spontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons.
title_full	Spontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons.
title_fullStr	Spontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons.
title_full_unstemmed	Spontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons.
title_sort	spontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/a60993a4b8004e7fb0c1e10f31634f48
work_keys_str_mv	AT emmanuelcruz spontaneousrecoveryoffearreversesextinctioninducedexcitabilityofinfralimbicneurons AT anavlopez spontaneousrecoveryoffearreversesextinctioninducedexcitabilityofinfralimbicneurons AT jamestporter spontaneousrecoveryoffearreversesextinctioninducedexcitabilityofinfralimbicneurons
_version_	1718414180605755392

Spontaneous recovery of fear reverses extinction-induced excitability of infralimbic neurons.

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