Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation

Abstract The severity and course of inflammatory processes differ between women and men, but the biochemical mechanisms underlying these sex differences are elusive. Prostaglandins (PG) and leukotrienes (LT) are lipid mediators linked to inflammation. We demonstrated superior LT biosynthesis in huma...

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Autores principales:	Simona Pace, Antonietta Rossi, Verena Krauth, Friederike Dehm, Fabiana Troisi, Rossella Bilancia, Christina Weinigel, Silke Rummler, Oliver Werz, Lidia Sautebin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a60cd34d072d4aff9b194d5994fd68ea
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spelling	oai:doaj.org-article:a60cd34d072d4aff9b194d5994fd68ea2021-12-02T11:52:17ZSex differences in prostaglandin biosynthesis in neutrophils during acute inflammation10.1038/s41598-017-03696-82045-2322https://doaj.org/article/a60cd34d072d4aff9b194d5994fd68ea2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03696-8https://doaj.org/toc/2045-2322Abstract The severity and course of inflammatory processes differ between women and men, but the biochemical mechanisms underlying these sex differences are elusive. Prostaglandins (PG) and leukotrienes (LT) are lipid mediators linked to inflammation. We demonstrated superior LT biosynthesis in human neutrophils and monocytes, and in mouse macrophages from females, and we confirmed these sex differences in vivo where female mice produced more LTs during zymosan-induced peritonitis versus males. Here, we report sex differences in PG production in neutrophils during acute inflammation. In the late phase (4–8 hrs) of mouse zymosan-induced peritonitis and rat carrageenan-induced pleurisy, PG levels in males were higher versus females, seemingly due to higher PG production in infiltrated neutrophils. Accordingly, human neutrophils from males produced more PGE2 than cells from females. Increased PG biosynthesis in males was accompanied by elevated cyclooxygenase (COX)-2 expression connected to increased nuclear factor-kappa B activation, and was abolished when LT synthesis was pharmacologically blocked, suggesting that elevated PG production in males might be caused by increased COX-2 expression and by shunting phenomena due to suppressed LT formation. Conclusively, our data reveal that the biosynthesis of pro-inflammatory PGs and LTs is conversely regulated by sex with consequences for the inflammatory response.Simona PaceAntonietta RossiVerena KrauthFriederike DehmFabiana TroisiRossella BilanciaChristina WeinigelSilke RummlerOliver WerzLidia SautebinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simona Pace Antonietta Rossi Verena Krauth Friederike Dehm Fabiana Troisi Rossella Bilancia Christina Weinigel Silke Rummler Oliver Werz Lidia Sautebin Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation
description	Abstract The severity and course of inflammatory processes differ between women and men, but the biochemical mechanisms underlying these sex differences are elusive. Prostaglandins (PG) and leukotrienes (LT) are lipid mediators linked to inflammation. We demonstrated superior LT biosynthesis in human neutrophils and monocytes, and in mouse macrophages from females, and we confirmed these sex differences in vivo where female mice produced more LTs during zymosan-induced peritonitis versus males. Here, we report sex differences in PG production in neutrophils during acute inflammation. In the late phase (4–8 hrs) of mouse zymosan-induced peritonitis and rat carrageenan-induced pleurisy, PG levels in males were higher versus females, seemingly due to higher PG production in infiltrated neutrophils. Accordingly, human neutrophils from males produced more PGE2 than cells from females. Increased PG biosynthesis in males was accompanied by elevated cyclooxygenase (COX)-2 expression connected to increased nuclear factor-kappa B activation, and was abolished when LT synthesis was pharmacologically blocked, suggesting that elevated PG production in males might be caused by increased COX-2 expression and by shunting phenomena due to suppressed LT formation. Conclusively, our data reveal that the biosynthesis of pro-inflammatory PGs and LTs is conversely regulated by sex with consequences for the inflammatory response.
format	article
author	Simona Pace Antonietta Rossi Verena Krauth Friederike Dehm Fabiana Troisi Rossella Bilancia Christina Weinigel Silke Rummler Oliver Werz Lidia Sautebin
author_facet	Simona Pace Antonietta Rossi Verena Krauth Friederike Dehm Fabiana Troisi Rossella Bilancia Christina Weinigel Silke Rummler Oliver Werz Lidia Sautebin
author_sort	Simona Pace
title	Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation
title_short	Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation
title_full	Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation
title_fullStr	Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation
title_full_unstemmed	Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation
title_sort	sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a60cd34d072d4aff9b194d5994fd68ea
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Sex differences in prostaglandin biosynthesis in neutrophils during acute inflammation

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