Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis

Abstract Background Abnormal proliferation and migration of human airway smooth muscle cells (HASMCs) play an important role in the development of childhood asthma. Long non-coding RNAs (lncRNAs) have been demonstrated to participate in HASMC proliferation and migration. We aimed to explore more eff...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xinfang Wang, Junsong Chen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Childhood asthma TUG1 miR-216a-3p SMURF2 HASMCs Cytology QH573-671
Acceso en línea:	https://doaj.org/article/a60d0e98ccd744a58f0a315e44dd5163
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a60d0e98ccd744a58f0a315e44dd5163
record_format	dspace
spelling	oai:doaj.org-article:a60d0e98ccd744a58f0a315e44dd51632021-11-14T12:27:14ZLong non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis10.1186/s12860-021-00396-02661-8850https://doaj.org/article/a60d0e98ccd744a58f0a315e44dd51632021-11-01T00:00:00Zhttps://doi.org/10.1186/s12860-021-00396-0https://doaj.org/toc/2661-8850Abstract Background Abnormal proliferation and migration of human airway smooth muscle cells (HASMCs) play an important role in the development of childhood asthma. Long non-coding RNAs (lncRNAs) have been demonstrated to participate in HASMC proliferation and migration. We aimed to explore more effects and molecular mechanism of taurine upregulated gene 1 (TUG1) in childhood asthma. Results TUG1 and SMURF2 were overexpressed and miR-216a-3p was downregulated in childhood asthma patients and PDGF-BB-stimulated HASMCs. TUG1 knockdown attenuated PDGF-BB-triggered proliferation and migration of HASMCs. MiR-216a-3p was targeted by TUG1, and miR-216a-3p suppression counteracted the repressive effects of TUG1 interference on proliferation and migration in PDGF-BB-treated HASMCs. SMURF2 was a downstream target of miR-216a-3p, and SMURF2 upregulation abated the inhibiting effects of miR-216a-3p on migration and proliferation in PDGF-BB-exposed HASMCs. TUG1 sponged miR-216a-3p to positively regulate SMURF2 expression. Conclusion TUG1 downregulation inhibited PDGF-BB-induced HASMC proliferation and migration by regulating miR-216a-3p/SMURF2 axis, offering novel insight into the potential application of TUG1 for childhood asthma treatment.Xinfang WangJunsong ChenBMCarticleChildhood asthmaTUG1miR-216a-3pSMURF2HASMCsCytologyQH573-671ENBMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Childhood asthma TUG1 miR-216a-3p SMURF2 HASMCs Cytology QH573-671
spellingShingle	Childhood asthma TUG1 miR-216a-3p SMURF2 HASMCs Cytology QH573-671 Xinfang Wang Junsong Chen Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis
description	Abstract Background Abnormal proliferation and migration of human airway smooth muscle cells (HASMCs) play an important role in the development of childhood asthma. Long non-coding RNAs (lncRNAs) have been demonstrated to participate in HASMC proliferation and migration. We aimed to explore more effects and molecular mechanism of taurine upregulated gene 1 (TUG1) in childhood asthma. Results TUG1 and SMURF2 were overexpressed and miR-216a-3p was downregulated in childhood asthma patients and PDGF-BB-stimulated HASMCs. TUG1 knockdown attenuated PDGF-BB-triggered proliferation and migration of HASMCs. MiR-216a-3p was targeted by TUG1, and miR-216a-3p suppression counteracted the repressive effects of TUG1 interference on proliferation and migration in PDGF-BB-treated HASMCs. SMURF2 was a downstream target of miR-216a-3p, and SMURF2 upregulation abated the inhibiting effects of miR-216a-3p on migration and proliferation in PDGF-BB-exposed HASMCs. TUG1 sponged miR-216a-3p to positively regulate SMURF2 expression. Conclusion TUG1 downregulation inhibited PDGF-BB-induced HASMC proliferation and migration by regulating miR-216a-3p/SMURF2 axis, offering novel insight into the potential application of TUG1 for childhood asthma treatment.
format	article
author	Xinfang Wang Junsong Chen
author_facet	Xinfang Wang Junsong Chen
author_sort	Xinfang Wang
title	Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis
title_short	Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis
title_full	Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis
title_fullStr	Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis
title_full_unstemmed	Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis
title_sort	long non-coding rna tug1 promotes proliferation and migration in pdgf-bb-stimulated hasmcs by regulating mir-216a-3p/smurf2 axis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/a60d0e98ccd744a58f0a315e44dd5163
work_keys_str_mv	AT xinfangwang longnoncodingrnatug1promotesproliferationandmigrationinpdgfbbstimulatedhasmcsbyregulatingmir216a3psmurf2axis AT junsongchen longnoncodingrnatug1promotesproliferationandmigrationinpdgfbbstimulatedhasmcsbyregulatingmir216a3psmurf2axis
_version_	1718429247893143552

Long non-coding RNA TUG1 promotes proliferation and migration in PDGF-BB-stimulated HASMCs by regulating miR-216a-3p/SMURF2 axis

Ejemplares similares