Neuroglobin in Retinal Neurodegeneration: A Potential Target in Therapeutic Approaches

Retinal neurodegeneration affects an increasing number of people worldwide causing vision impairments and blindness, reducing quality of life, and generating a great economic challenge. Due to the complexity of the tissue, and the diversity of retinal neurodegenerative diseases in terms of etiology...

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Autores principales:	Virginia Solar Fernandez, Maria Marino, Marco Fiocchetti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neuroglobin retinal neurodegeneration stress response Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a60fdaa5de1440168b6a2a928c83d407
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spelling	oai:doaj.org-article:a60fdaa5de1440168b6a2a928c83d4072021-11-25T17:12:47ZNeuroglobin in Retinal Neurodegeneration: A Potential Target in Therapeutic Approaches10.3390/cells101132002073-4409https://doaj.org/article/a60fdaa5de1440168b6a2a928c83d4072021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3200https://doaj.org/toc/2073-4409Retinal neurodegeneration affects an increasing number of people worldwide causing vision impairments and blindness, reducing quality of life, and generating a great economic challenge. Due to the complexity of the tissue, and the diversity of retinal neurodegenerative diseases in terms of etiology and clinical presentation, so far, there are no cures and only a few early pathological markers have been identified. Increasing efforts have been made to identify and potentiate endogenous protective mechanisms or to abolish detrimental stress responses to preserve retinal structure and function. The discovering of the intracellular monomeric globin neuroglobin (NGB), found at high concentration in the retina, has opened new possibilities for the treatment of retinal disease. Indeed, the NGB capability to reversibly bind oxygen and its neuroprotective function against several types of insults including oxidative stress, ischemia, and neurodegenerative conditions have raised the interest in the possible role of the globin as oxygen supplier in the retina and as a target for retinal neurodegeneration. Here, we provide the undercurrent knowledge on NGB distribution in retinal layers and the evidence about the connection between NGB level modulation and the functional outcome in terms of retinal neuroprotection to provide a novel therapeutic/preventive target for visual pathway degenerative disease.Virginia Solar FernandezMaria MarinoMarco FiocchettiMDPI AGarticleneuroglobinretinal neurodegenerationstress responseBiology (General)QH301-705.5ENCells, Vol 10, Iss 3200, p 3200 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuroglobin retinal neurodegeneration stress response Biology (General) QH301-705.5
spellingShingle	neuroglobin retinal neurodegeneration stress response Biology (General) QH301-705.5 Virginia Solar Fernandez Maria Marino Marco Fiocchetti Neuroglobin in Retinal Neurodegeneration: A Potential Target in Therapeutic Approaches
description	Retinal neurodegeneration affects an increasing number of people worldwide causing vision impairments and blindness, reducing quality of life, and generating a great economic challenge. Due to the complexity of the tissue, and the diversity of retinal neurodegenerative diseases in terms of etiology and clinical presentation, so far, there are no cures and only a few early pathological markers have been identified. Increasing efforts have been made to identify and potentiate endogenous protective mechanisms or to abolish detrimental stress responses to preserve retinal structure and function. The discovering of the intracellular monomeric globin neuroglobin (NGB), found at high concentration in the retina, has opened new possibilities for the treatment of retinal disease. Indeed, the NGB capability to reversibly bind oxygen and its neuroprotective function against several types of insults including oxidative stress, ischemia, and neurodegenerative conditions have raised the interest in the possible role of the globin as oxygen supplier in the retina and as a target for retinal neurodegeneration. Here, we provide the undercurrent knowledge on NGB distribution in retinal layers and the evidence about the connection between NGB level modulation and the functional outcome in terms of retinal neuroprotection to provide a novel therapeutic/preventive target for visual pathway degenerative disease.
format	article
author	Virginia Solar Fernandez Maria Marino Marco Fiocchetti
author_facet	Virginia Solar Fernandez Maria Marino Marco Fiocchetti
author_sort	Virginia Solar Fernandez
title	Neuroglobin in Retinal Neurodegeneration: A Potential Target in Therapeutic Approaches
title_short	Neuroglobin in Retinal Neurodegeneration: A Potential Target in Therapeutic Approaches
title_full	Neuroglobin in Retinal Neurodegeneration: A Potential Target in Therapeutic Approaches
title_fullStr	Neuroglobin in Retinal Neurodegeneration: A Potential Target in Therapeutic Approaches
title_full_unstemmed	Neuroglobin in Retinal Neurodegeneration: A Potential Target in Therapeutic Approaches
title_sort	neuroglobin in retinal neurodegeneration: a potential target in therapeutic approaches
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a60fdaa5de1440168b6a2a928c83d407
work_keys_str_mv	AT virginiasolarfernandez neuroglobininretinalneurodegenerationapotentialtargetintherapeuticapproaches AT mariamarino neuroglobininretinalneurodegenerationapotentialtargetintherapeuticapproaches AT marcofiocchetti neuroglobininretinalneurodegenerationapotentialtargetintherapeuticapproaches
_version_	1718412609121681408

Neuroglobin in Retinal Neurodegeneration: A Potential Target in Therapeutic Approaches

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