Molecularly defined extraintestinal pathogenic Escherichia coli status predicts virulence in a murine sepsis model better than does virotype, individual virulence genes, or clonal subset among E. coli ST131 isolates

Molecularly defined extraintestinal pathogenic Escherichia coli status predicts virulence in a murine sepsis model better than does virotype, individual virulence genes, or clonal subset among E. coli ST131 isolates

Background: Escherichia coli ST131, mainly its H30 clade, is the leading cause of extraintestinal E. coli infections but its correlates of virulence are undefined. Materials and methods: We tested in a murine sepsis model 84 ST131 isolates that differed by country of origin (Spain vs. USA), clonal s...

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Autores principales: Irene Merino, Stephen B. Porter, Brian Johnston, Connie Clabots, Paul Thuras, Patricia Ruiz-Garbajosa, Rafael Cantón, James R. Johnson
Formato: article
Lenguaje:EN
Publicado: Taylor & Francis Group 2020
Materias:
e. coli
virulence
expec
mouse sepsis model
Infectious and parasitic diseases
RC109-216
Acceso en línea:https://doaj.org/article/a6121412f42142cf8f2a4f9e1c9088a3
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