Association Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study

Jia Yu,1,* Hongyan Sun,2,* Fei Shang,2,* Haishu Wu,2 Hongfei Shi,2 Liyun Ren,1 Yan He,1 Mingzhi Zhang,1 Hao Peng1 1Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Su...

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Autores principales:	Yu J, Sun H, Shang F, Wu H, Shi H, Ren L, He Y, Zhang M, Peng H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	vascular aging glucose metabolism chines fasting glucose. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/a612ff7b2d8e4f099b89183f82878c80
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spelling	oai:doaj.org-article:a612ff7b2d8e4f099b89183f82878c802021-12-02T09:54:38ZAssociation Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study1178-1998https://doaj.org/article/a612ff7b2d8e4f099b89183f82878c802019-11-01T00:00:00Zhttps://www.dovepress.com/association-between-glucose-metabolism-and-vascular-aging-in-chinese-a-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jia Yu,1,* Hongyan Sun,2,* Fei Shang,2,* Haishu Wu,2 Hongfei Shi,2 Liyun Ren,1 Yan He,1 Mingzhi Zhang,1 Hao Peng1 1Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, People’s Republic of China; 2Center for Disease Prevention and Control of Tianning District, Changzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao PengDepartment of Epidemiology, School of Public Health And Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, 199 Renai Road, Industrial Park, Suzhou 215123, People’s Republic of ChinaTel +86 512 6588 0078Fax +86 512 6588 0052Email penghao@suda.edu.cnMingzhi ZhangDepartment of Biostatistics, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, 199 Renai Road, Industrial Park, Suzhou 215123, People’s Republic of ChinaTel +86 512 6588 0079Fax +86 512 6588 0052Email zhangmingzhi@suda.edu.cnAim: Fasting glucose has been associated with vascular aging, but the association between HbA1c and vascular aging has been limitedly studied in Chinese and other ethnic populations. We aimed to examine this association in a large sample of Chinese adults.Methods: In the Tianning Cohort (N=5142), fasting glucose, HbA1c, carotid-femoral pulse wave velocity (cfPWV), and pulse pressure (PP) were measured. Vascular aging was defined as having the highest quartile level of cfPWV or PP. We applied quantile regression models to examine the association between glucose metabolism and vascular aging.Results: The median cfPWV was significantly increased as increasing quintiles of fasting glucose (β=0.14, P<0.001) and HbA1c (β=0.07, P=0.0056), respectively. Per 1-mmol/L increment of fasting glucose was significantly associated with a higher risk of having vascular aging defined by cfPWV (OR=1.05, P=0.022), PP (OR=1.06, P=0.048), or either (OR=1.08, P=0.002). Similarly, per 1% increment of HbA1c was significantly associated with a higher risk of having vascular aging defined by cfPWV (OR=1.06, P=0.044), PP (OR=1.10, P=0.012), or either (OR=1.12, P=0.042).Conclusion: Glucose metabolism was significantly and positively associated with vascular aging in Chinese adults, but the causality is uncertain.Keywords: vascular aging, glucose metabolism, Chinese, fasting glucoseYu JSun HShang FWu HShi HRen LHe YZhang MPeng HDove Medical Pressarticlevascular agingglucose metabolismchinesfasting glucose.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1937-1946 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	vascular aging glucose metabolism chines fasting glucose. Geriatrics RC952-954.6
spellingShingle	vascular aging glucose metabolism chines fasting glucose. Geriatrics RC952-954.6 Yu J Sun H Shang F Wu H Shi H Ren L He Y Zhang M Peng H Association Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study
description	Jia Yu,1,* Hongyan Sun,2,* Fei Shang,2,* Haishu Wu,2 Hongfei Shi,2 Liyun Ren,1 Yan He,1 Mingzhi Zhang,1 Hao Peng1 1Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, People’s Republic of China; 2Center for Disease Prevention and Control of Tianning District, Changzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hao PengDepartment of Epidemiology, School of Public Health And Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, 199 Renai Road, Industrial Park, Suzhou 215123, People’s Republic of ChinaTel +86 512 6588 0078Fax +86 512 6588 0052Email penghao@suda.edu.cnMingzhi ZhangDepartment of Biostatistics, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, 199 Renai Road, Industrial Park, Suzhou 215123, People’s Republic of ChinaTel +86 512 6588 0079Fax +86 512 6588 0052Email zhangmingzhi@suda.edu.cnAim: Fasting glucose has been associated with vascular aging, but the association between HbA1c and vascular aging has been limitedly studied in Chinese and other ethnic populations. We aimed to examine this association in a large sample of Chinese adults.Methods: In the Tianning Cohort (N=5142), fasting glucose, HbA1c, carotid-femoral pulse wave velocity (cfPWV), and pulse pressure (PP) were measured. Vascular aging was defined as having the highest quartile level of cfPWV or PP. We applied quantile regression models to examine the association between glucose metabolism and vascular aging.Results: The median cfPWV was significantly increased as increasing quintiles of fasting glucose (β=0.14, P<0.001) and HbA1c (β=0.07, P=0.0056), respectively. Per 1-mmol/L increment of fasting glucose was significantly associated with a higher risk of having vascular aging defined by cfPWV (OR=1.05, P=0.022), PP (OR=1.06, P=0.048), or either (OR=1.08, P=0.002). Similarly, per 1% increment of HbA1c was significantly associated with a higher risk of having vascular aging defined by cfPWV (OR=1.06, P=0.044), PP (OR=1.10, P=0.012), or either (OR=1.12, P=0.042).Conclusion: Glucose metabolism was significantly and positively associated with vascular aging in Chinese adults, but the causality is uncertain.Keywords: vascular aging, glucose metabolism, Chinese, fasting glucose
format	article
author	Yu J Sun H Shang F Wu H Shi H Ren L He Y Zhang M Peng H
author_facet	Yu J Sun H Shang F Wu H Shi H Ren L He Y Zhang M Peng H
author_sort	Yu J
title	Association Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study
title_short	Association Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study
title_full	Association Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study
title_fullStr	Association Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study
title_full_unstemmed	Association Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study
title_sort	association between glucose metabolism and vascular aging in chinese adults: a cross-sectional analysis in the tianning cohort study
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/a612ff7b2d8e4f099b89183f82878c80
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Association Between Glucose Metabolism And Vascular Aging In Chinese Adults: A Cross-Sectional Analysis In The Tianning Cohort Study

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