Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis

The recent increases in cancer incidences have been linked to lifestyle changes that result in obesity and metabolic syndrome. It is now evident that these trends are associated with the profound changes that occur in the intestinal microbiome, producing altered microbial population signatures that...

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Autores principales:	Shakhzada Ibragimova, Revathy Ramachandran, Fahad R. Ali, Leonard Lipovich, Samuel B. Ho
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	microbiome dietary pattern Western diet plant-based diet colorectal cancer alcohol Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a61631136e424cca84b87c8dfcadc643
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spelling	oai:doaj.org-article:a61631136e424cca84b87c8dfcadc6432021-11-12T06:18:05ZDietary Patterns and Associated Microbiome Changes that Promote Oncogenesis2296-634X10.3389/fcell.2021.725821https://doaj.org/article/a61631136e424cca84b87c8dfcadc6432021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.725821/fullhttps://doaj.org/toc/2296-634XThe recent increases in cancer incidences have been linked to lifestyle changes that result in obesity and metabolic syndrome. It is now evident that these trends are associated with the profound changes that occur in the intestinal microbiome, producing altered microbial population signatures that interact, directly or indirectly, with potentially pro-carcinogenic molecular pathways of transcription, proliferation, and inflammation. The effects of the entire gut microbial population on overall health are complex, but individual bacteria are known to play important and definable roles. Recent detailed examinations of a large number of subjects show a tight correlation between habitual diets, fecal microbiome signatures, and markers of metabolic health. Diets that score higher in healthfulness or diversity such as plant-based diets, have altered ratios of specific bacteria, including an increase in short-chain fatty acid producers, which in turn have been linked to improved metabolic markers and lowered cancer risk. Contrarily, numerous studies have implicated less healthy, lower-scoring diets such as the Western diet with reduced intestinal epithelial defenses and promotion of specific bacteria that affect carcinogenic pathways. In this review, we will describe how different dietary patterns affect microbial populations in the gut and illustrate the subsequent impact of bacterial products and metabolites on molecular pathways of cancer development, both locally in the gut and systemically in distant organs.Shakhzada IbragimovaRevathy RamachandranFahad R. AliLeonard LipovichSamuel B. HoSamuel B. HoFrontiers Media S.A.articlemicrobiomedietary patternWestern dietplant-based dietcolorectal canceralcoholBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microbiome dietary pattern Western diet plant-based diet colorectal cancer alcohol Biology (General) QH301-705.5
spellingShingle	microbiome dietary pattern Western diet plant-based diet colorectal cancer alcohol Biology (General) QH301-705.5 Shakhzada Ibragimova Revathy Ramachandran Fahad R. Ali Leonard Lipovich Samuel B. Ho Samuel B. Ho Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
description	The recent increases in cancer incidences have been linked to lifestyle changes that result in obesity and metabolic syndrome. It is now evident that these trends are associated with the profound changes that occur in the intestinal microbiome, producing altered microbial population signatures that interact, directly or indirectly, with potentially pro-carcinogenic molecular pathways of transcription, proliferation, and inflammation. The effects of the entire gut microbial population on overall health are complex, but individual bacteria are known to play important and definable roles. Recent detailed examinations of a large number of subjects show a tight correlation between habitual diets, fecal microbiome signatures, and markers of metabolic health. Diets that score higher in healthfulness or diversity such as plant-based diets, have altered ratios of specific bacteria, including an increase in short-chain fatty acid producers, which in turn have been linked to improved metabolic markers and lowered cancer risk. Contrarily, numerous studies have implicated less healthy, lower-scoring diets such as the Western diet with reduced intestinal epithelial defenses and promotion of specific bacteria that affect carcinogenic pathways. In this review, we will describe how different dietary patterns affect microbial populations in the gut and illustrate the subsequent impact of bacterial products and metabolites on molecular pathways of cancer development, both locally in the gut and systemically in distant organs.
format	article
author	Shakhzada Ibragimova Revathy Ramachandran Fahad R. Ali Leonard Lipovich Samuel B. Ho Samuel B. Ho
author_facet	Shakhzada Ibragimova Revathy Ramachandran Fahad R. Ali Leonard Lipovich Samuel B. Ho Samuel B. Ho
author_sort	Shakhzada Ibragimova
title	Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
title_short	Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
title_full	Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
title_fullStr	Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
title_full_unstemmed	Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis
title_sort	dietary patterns and associated microbiome changes that promote oncogenesis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a61631136e424cca84b87c8dfcadc643
work_keys_str_mv	AT shakhzadaibragimova dietarypatternsandassociatedmicrobiomechangesthatpromoteoncogenesis AT revathyramachandran dietarypatternsandassociatedmicrobiomechangesthatpromoteoncogenesis AT fahadrali dietarypatternsandassociatedmicrobiomechangesthatpromoteoncogenesis AT leonardlipovich dietarypatternsandassociatedmicrobiomechangesthatpromoteoncogenesis AT samuelbho dietarypatternsandassociatedmicrobiomechangesthatpromoteoncogenesis AT samuelbho dietarypatternsandassociatedmicrobiomechangesthatpromoteoncogenesis
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Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis

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