Infection with Blastocystis spp. and its association with enteric infections and environmental enteric dysfunction among slum-dwelling malnourished adults in Bangladesh.

<h4>Background</h4>Blastocystis spp. (Blastocystis) is a widely distributed gastrointestinal protist frequently reported in countries with tropical and sub-tropical climate. We sought to determine the factors associated with Blastocystis infection and investigate its role on biomarkers o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shah Mohammad Fahim, Md Amran Gazi, Md Mehedi Hasan, Md Ashraful Alam, Subhasish Das, Mustafa Mahfuz, M Masudur Rahman, Rashidul Haque, Shafiqul Alam Sarker, Tahmeed Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/a617efaefbd340d89607581c771acb55
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a617efaefbd340d89607581c771acb55
record_format	dspace
spelling	oai:doaj.org-article:a617efaefbd340d89607581c771acb552021-12-02T20:24:17ZInfection with Blastocystis spp. and its association with enteric infections and environmental enteric dysfunction among slum-dwelling malnourished adults in Bangladesh.1935-27271935-273510.1371/journal.pntd.0009684https://doaj.org/article/a617efaefbd340d89607581c771acb552021-08-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009684https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>Blastocystis spp. (Blastocystis) is a widely distributed gastrointestinal protist frequently reported in countries with tropical and sub-tropical climate. We sought to determine the factors associated with Blastocystis infection and investigate its role on biomarkers of intestinal health among slum-dwelling malnourished adults in Bangladesh.<h4>Methodology</h4>Total 524 malnourished adults with a body mass index ≤18.5 kg/m2 were included in this analysis. Presence of Blastocystis in feces was evaluated by TaqMan Array Card assays.<h4>Principal findings</h4>Blastocystis was tested positive in 78.6% of the participants. Prevalence of infection with atypical strains of enteropathogenic Escherichia coli (aEPEC) (56% vs. 38%, p<0.001), and Trichuris trichiura (28% vs. 15%, p-value = 0.02) was significantly greater in adults with Blastocystis, while Giardia intestinalis was significantly lower (8% vs. 14%, p-value = 0.04) in Blastocystis positive adults. Malnourished adults who were living in households with high crowding index (aOR = 2.18; 95% CI = 1.11, 4.65; p-value = 0.03), and infected with aEPEC (aOR = 2.14; 95% CI = 1.35, 3.44; p-value = 0.001) and Trichuris trichiura (aOR = 1.97; 95% CI = 1.08, 3.77; p = 0.03) were more likely to be infected with Blastocystis. A significant negative relationship was observed between Blastocystis and fecal concentrations of alpha-1 antitrypsin (β = -0.1; 95% CI = -1.7, -0.1; p-value<0.001) and Reg1B (β = -3.6; 95% CI = -6.9, -3.0; p-value = 0.03).<h4>Conclusions</h4>The study findings suggest that the presence of Blastocystis in human intestine influences gut health and may have potential pathogenic role in presence of other pathogens.Shah Mohammad FahimMd Amran GaziMd Mehedi HasanMd Ashraful AlamSubhasish DasMustafa MahfuzM Masudur RahmanRashidul HaqueShafiqul Alam SarkerTahmeed AhmedPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009684 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Shah Mohammad Fahim Md Amran Gazi Md Mehedi Hasan Md Ashraful Alam Subhasish Das Mustafa Mahfuz M Masudur Rahman Rashidul Haque Shafiqul Alam Sarker Tahmeed Ahmed Infection with Blastocystis spp. and its association with enteric infections and environmental enteric dysfunction among slum-dwelling malnourished adults in Bangladesh.
description	<h4>Background</h4>Blastocystis spp. (Blastocystis) is a widely distributed gastrointestinal protist frequently reported in countries with tropical and sub-tropical climate. We sought to determine the factors associated with Blastocystis infection and investigate its role on biomarkers of intestinal health among slum-dwelling malnourished adults in Bangladesh.<h4>Methodology</h4>Total 524 malnourished adults with a body mass index ≤18.5 kg/m2 were included in this analysis. Presence of Blastocystis in feces was evaluated by TaqMan Array Card assays.<h4>Principal findings</h4>Blastocystis was tested positive in 78.6% of the participants. Prevalence of infection with atypical strains of enteropathogenic Escherichia coli (aEPEC) (56% vs. 38%, p<0.001), and Trichuris trichiura (28% vs. 15%, p-value = 0.02) was significantly greater in adults with Blastocystis, while Giardia intestinalis was significantly lower (8% vs. 14%, p-value = 0.04) in Blastocystis positive adults. Malnourished adults who were living in households with high crowding index (aOR = 2.18; 95% CI = 1.11, 4.65; p-value = 0.03), and infected with aEPEC (aOR = 2.14; 95% CI = 1.35, 3.44; p-value = 0.001) and Trichuris trichiura (aOR = 1.97; 95% CI = 1.08, 3.77; p = 0.03) were more likely to be infected with Blastocystis. A significant negative relationship was observed between Blastocystis and fecal concentrations of alpha-1 antitrypsin (β = -0.1; 95% CI = -1.7, -0.1; p-value<0.001) and Reg1B (β = -3.6; 95% CI = -6.9, -3.0; p-value = 0.03).<h4>Conclusions</h4>The study findings suggest that the presence of Blastocystis in human intestine influences gut health and may have potential pathogenic role in presence of other pathogens.
format	article
author	Shah Mohammad Fahim Md Amran Gazi Md Mehedi Hasan Md Ashraful Alam Subhasish Das Mustafa Mahfuz M Masudur Rahman Rashidul Haque Shafiqul Alam Sarker Tahmeed Ahmed
author_facet	Shah Mohammad Fahim Md Amran Gazi Md Mehedi Hasan Md Ashraful Alam Subhasish Das Mustafa Mahfuz M Masudur Rahman Rashidul Haque Shafiqul Alam Sarker Tahmeed Ahmed
author_sort	Shah Mohammad Fahim
title	Infection with Blastocystis spp. and its association with enteric infections and environmental enteric dysfunction among slum-dwelling malnourished adults in Bangladesh.
title_short	Infection with Blastocystis spp. and its association with enteric infections and environmental enteric dysfunction among slum-dwelling malnourished adults in Bangladesh.
title_full	Infection with Blastocystis spp. and its association with enteric infections and environmental enteric dysfunction among slum-dwelling malnourished adults in Bangladesh.
title_fullStr	Infection with Blastocystis spp. and its association with enteric infections and environmental enteric dysfunction among slum-dwelling malnourished adults in Bangladesh.
title_full_unstemmed	Infection with Blastocystis spp. and its association with enteric infections and environmental enteric dysfunction among slum-dwelling malnourished adults in Bangladesh.
title_sort	infection with blastocystis spp. and its association with enteric infections and environmental enteric dysfunction among slum-dwelling malnourished adults in bangladesh.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a617efaefbd340d89607581c771acb55
work_keys_str_mv	AT shahmohammadfahim infectionwithblastocystissppanditsassociationwithentericinfectionsandenvironmentalentericdysfunctionamongslumdwellingmalnourishedadultsinbangladesh AT mdamrangazi infectionwithblastocystissppanditsassociationwithentericinfectionsandenvironmentalentericdysfunctionamongslumdwellingmalnourishedadultsinbangladesh AT mdmehedihasan infectionwithblastocystissppanditsassociationwithentericinfectionsandenvironmentalentericdysfunctionamongslumdwellingmalnourishedadultsinbangladesh AT mdashrafulalam infectionwithblastocystissppanditsassociationwithentericinfectionsandenvironmentalentericdysfunctionamongslumdwellingmalnourishedadultsinbangladesh AT subhasishdas infectionwithblastocystissppanditsassociationwithentericinfectionsandenvironmentalentericdysfunctionamongslumdwellingmalnourishedadultsinbangladesh AT mustafamahfuz infectionwithblastocystissppanditsassociationwithentericinfectionsandenvironmentalentericdysfunctionamongslumdwellingmalnourishedadultsinbangladesh AT mmasudurrahman infectionwithblastocystissppanditsassociationwithentericinfectionsandenvironmentalentericdysfunctionamongslumdwellingmalnourishedadultsinbangladesh AT rashidulhaque infectionwithblastocystissppanditsassociationwithentericinfectionsandenvironmentalentericdysfunctionamongslumdwellingmalnourishedadultsinbangladesh AT shafiqulalamsarker infectionwithblastocystissppanditsassociationwithentericinfectionsandenvironmentalentericdysfunctionamongslumdwellingmalnourishedadultsinbangladesh AT tahmeedahmed infectionwithblastocystissppanditsassociationwithentericinfectionsandenvironmentalentericdysfunctionamongslumdwellingmalnourishedadultsinbangladesh
_version_	1718374068729675776

Infection with Blastocystis spp. and its association with enteric infections and environmental enteric dysfunction among slum-dwelling malnourished adults in Bangladesh.

Ejemplares similares