Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions

Protein-based biosensors have been engineered to interrogate cellular signaling and manipulate function. Here the authors demonstrate iSNAP, a tool to detect tyrosine phosphorylation and activate desired protein enzymes allowing the control of phagocytosis in macrophages.

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Detalles Bibliográficos
Autores principales:	Jie Sun, Lei Lei, Chih-Ming Tsai, Yi Wang, Yiwen Shi, Mingxing Ouyang, Shaoying Lu, Jihye Seong, Tae-Jin Kim, Pengzhi Wang, Min Huang, Xiangdong Xu, Victor Nizet, Shu Chien, Yingxiao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a61cadf591784cc49a38c596b72beffb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:a61cadf591784cc49a38c596b72beffb2021-12-02T15:38:40ZEngineered proteins with sensing and activating modules for automated reprogramming of cellular functions10.1038/s41467-017-00569-62041-1723https://doaj.org/article/a61cadf591784cc49a38c596b72beffb2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00569-6https://doaj.org/toc/2041-1723Protein-based biosensors have been engineered to interrogate cellular signaling and manipulate function. Here the authors demonstrate iSNAP, a tool to detect tyrosine phosphorylation and activate desired protein enzymes allowing the control of phagocytosis in macrophages.Jie SunLei LeiChih-Ming TsaiYi WangYiwen ShiMingxing OuyangShaoying LuJihye SeongTae-Jin KimPengzhi WangMin HuangXiangdong XuVictor NizetShu ChienYingxiao WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jie Sun Lei Lei Chih-Ming Tsai Yi Wang Yiwen Shi Mingxing Ouyang Shaoying Lu Jihye Seong Tae-Jin Kim Pengzhi Wang Min Huang Xiangdong Xu Victor Nizet Shu Chien Yingxiao Wang Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions
description	Protein-based biosensors have been engineered to interrogate cellular signaling and manipulate function. Here the authors demonstrate iSNAP, a tool to detect tyrosine phosphorylation and activate desired protein enzymes allowing the control of phagocytosis in macrophages.
format	article
author	Jie Sun Lei Lei Chih-Ming Tsai Yi Wang Yiwen Shi Mingxing Ouyang Shaoying Lu Jihye Seong Tae-Jin Kim Pengzhi Wang Min Huang Xiangdong Xu Victor Nizet Shu Chien Yingxiao Wang
author_facet	Jie Sun Lei Lei Chih-Ming Tsai Yi Wang Yiwen Shi Mingxing Ouyang Shaoying Lu Jihye Seong Tae-Jin Kim Pengzhi Wang Min Huang Xiangdong Xu Victor Nizet Shu Chien Yingxiao Wang
author_sort	Jie Sun
title	Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions
title_short	Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions
title_full	Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions
title_fullStr	Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions
title_full_unstemmed	Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions
title_sort	engineered proteins with sensing and activating modules for automated reprogramming of cellular functions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a61cadf591784cc49a38c596b72beffb
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Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions

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