CSC software corrects off-target mediated gRNA depletion in CRISPR-Cas9 essentiality screens
Off-target effects often confound the interpretation of CRISPR screens. Here, the authors introduce a computational method that corrects for off-targets in gRNA depletion assays, circumventing the need to completely discard unspecific guides.
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| Auteurs principaux: | , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2021
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| Sujets: | |
| Accès en ligne: | https://doaj.org/article/a61d9a2685ec4a239acd6ead2d346875 |
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