Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice

Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice

ABSTRACT Preexisting immunity against dengue virus or West Nile virus was previously reported to mediate antibody-dependent enhancement (ADE) of Zika virus (ZIKV) infection in a mouse model. We show here that ZIKV-immune plasma samples from both symptomatic and asymptomatic individuals mediated ZIKV...

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Bibliographic Details
Main Authors: Byoung-Shik Shim, Young-Chan Kwon, Michael J. Ricciardi, Mars Stone, Yuka Otsuka, Fatma Berri, Jaclyn M. Kwal, Diogo M. Magnani, Cody B. Jackson, Audrey S. Richard, Philip Norris, Michael Busch, Christine L. Curry, Michael Farzan, David Watkins, Hyeryun Choe
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
Zika virus
antibody-dependent enhancement
congenital disease
homotypic
microcephaly
pregnancy
Microbiology
QR1-502
Online Access:https://doaj.org/article/a6218489bb8a42a58651197c773f907b
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