Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models

The intraductal papillary mucinous neoplasm (IPMN) is attracting research attention because of its increasing incidence and proven potential to progress into invasive pancreatic ductal adenocarcinoma (PDAC). In this review, we summarized the key signaling pathways or protein complexes (GPCR, TGF, SW...

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Autores principales:	Jin Li, Tao Wei, Jian Zhang, Tingbo Liang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	IPMN genetic mouse models molecular signature pathogenesis pancreatic cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a624a16a7ffe452791794627b7434ea2
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spelling	oai:doaj.org-article:a624a16a7ffe452791794627b7434ea22021-11-11T15:27:35ZIntraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models10.3390/cancers132152962072-6694https://doaj.org/article/a624a16a7ffe452791794627b7434ea22021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5296https://doaj.org/toc/2072-6694The intraductal papillary mucinous neoplasm (IPMN) is attracting research attention because of its increasing incidence and proven potential to progress into invasive pancreatic ductal adenocarcinoma (PDAC). In this review, we summarized the key signaling pathways or protein complexes (GPCR, TGF, SWI/SNF, WNT, and PI3K) that appear to be involved in IPMN pathogenesis. In addition, we collected information regarding all the genetic mouse models that mimic the human IPMN phenotype with specific immunohistochemistry techniques. The mouse models enable us to gain insight into the complex mechanism of the origin of IPMN, revealing that it can be developed from both acinar cells and duct cells according to different models. Furthermore, recent genomic studies describe the potential mechanism by which heterogeneous IPMN gives rise to malignant carcinoma through sequential, branch-off, or de novo approaches. The most intractable problem is that the risk of malignancy persists to some extent even if the primary IPMN is excised with a perfect margin, calling for the re-evaluation and improvement of diagnostic, pre-emptive, and therapeutic measures.Jin LiTao WeiJian ZhangTingbo LiangMDPI AGarticleIPMNgenetic mouse modelsmolecular signaturepathogenesispancreatic cancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5296, p 5296 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	IPMN genetic mouse models molecular signature pathogenesis pancreatic cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	IPMN genetic mouse models molecular signature pathogenesis pancreatic cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jin Li Tao Wei Jian Zhang Tingbo Liang Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models
description	The intraductal papillary mucinous neoplasm (IPMN) is attracting research attention because of its increasing incidence and proven potential to progress into invasive pancreatic ductal adenocarcinoma (PDAC). In this review, we summarized the key signaling pathways or protein complexes (GPCR, TGF, SWI/SNF, WNT, and PI3K) that appear to be involved in IPMN pathogenesis. In addition, we collected information regarding all the genetic mouse models that mimic the human IPMN phenotype with specific immunohistochemistry techniques. The mouse models enable us to gain insight into the complex mechanism of the origin of IPMN, revealing that it can be developed from both acinar cells and duct cells according to different models. Furthermore, recent genomic studies describe the potential mechanism by which heterogeneous IPMN gives rise to malignant carcinoma through sequential, branch-off, or de novo approaches. The most intractable problem is that the risk of malignancy persists to some extent even if the primary IPMN is excised with a perfect margin, calling for the re-evaluation and improvement of diagnostic, pre-emptive, and therapeutic measures.
format	article
author	Jin Li Tao Wei Jian Zhang Tingbo Liang
author_facet	Jin Li Tao Wei Jian Zhang Tingbo Liang
author_sort	Jin Li
title	Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models
title_short	Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models
title_full	Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models
title_fullStr	Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models
title_full_unstemmed	Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models
title_sort	intraductal papillary mucinous neoplasms of the pancreas: a review of their genetic characteristics and mouse models
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a624a16a7ffe452791794627b7434ea2
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Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Review of Their Genetic Characteristics and Mouse Models

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