THE ROLE OF THE STRUCTURAL PROTEINS IN THE NON-VIRAEMIC TRANSMISSION OF TICK-BORNE ENCEPHALITIS VIRUS

There are 3 subtypes of tick-borne encephalitis virus (TBEV) distinguished, at present time: European (EU), Siberian (SIB) and Far Eastern (FE). The former one is associated with Ixodes ricinus tick, whereas the latter two - with I. persulcatus. The circulation of TBEV in nature is mediated by the n...

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Autores principales:	M. A. Khasnatinov, S. Havlikova, A. Tuplin, M. Kazimirova, N. Goonavardane, M. Slovak, B. Klempa, I. M. Jones, M. Labuda, E. A. Gould, T. S. Gritsun
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	tick-borne encephalitis virus transmission recombinant virus Science Q
Acceso en línea:	https://doaj.org/article/a624e7cd27e14f93924e1f034a27fc10
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spelling	oai:doaj.org-article:a624e7cd27e14f93924e1f034a27fc102021-11-23T06:14:24ZTHE ROLE OF THE STRUCTURAL PROTEINS IN THE NON-VIRAEMIC TRANSMISSION OF TICK-BORNE ENCEPHALITIS VIRUS2541-94202587-9596https://doaj.org/article/a624e7cd27e14f93924e1f034a27fc102012-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1161https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596There are 3 subtypes of tick-borne encephalitis virus (TBEV) distinguished, at present time: European (EU), Siberian (SIB) and Far Eastern (FE). The former one is associated with Ixodes ricinus tick, whereas the latter two - with I. persulcatus. The circulation of TBEV in nature is mediated by the non-viraemic transmission, between infected and. uninfected ticks co-feeding on the same hosts and. it was shown that transmission rate of «Hypr» strain (EU subtype) is much higher than rate of «Vasilchenko» strain (SIB subtype) - 60 and 5 % respectively. To reveal the viral determinants of transmission efficacy, we constructed the series of recombinant viruses with gradually exchanged genes coding structural (str) and. non-structural (ns) viral proteins. The recombinant virus Hypr[str]Vs[ns] achieved the rate of non-viraemic transmission of 70 %. The introduction of separate structural genes of Hypr into Vs infectious clone has enhanced the transmission efficacy as well, though not to such extent as entire structural region but up to 33 % only. Thus, it was shown that efficacy of non-viraemic transmission of TBEV depends from properties of viral structural proteins mainly.M. A. KhasnatinovS. HavlikovaA. TuplinM. KazimirovaN. GoonavardaneM. SlovakB. KlempaI. M. JonesM. LabudaE. A. GouldT. S. GritsunScientific Сentre for Family Health and Human Reproduction Problemsarticletick-borne encephalitis virustransmissionrecombinant virusScienceQRUActa Biomedica Scientifica, Vol 0, Iss 5(1), Pp 331-334 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	tick-borne encephalitis virus transmission recombinant virus Science Q
spellingShingle	tick-borne encephalitis virus transmission recombinant virus Science Q M. A. Khasnatinov S. Havlikova A. Tuplin M. Kazimirova N. Goonavardane M. Slovak B. Klempa I. M. Jones M. Labuda E. A. Gould T. S. Gritsun THE ROLE OF THE STRUCTURAL PROTEINS IN THE NON-VIRAEMIC TRANSMISSION OF TICK-BORNE ENCEPHALITIS VIRUS
description	There are 3 subtypes of tick-borne encephalitis virus (TBEV) distinguished, at present time: European (EU), Siberian (SIB) and Far Eastern (FE). The former one is associated with Ixodes ricinus tick, whereas the latter two - with I. persulcatus. The circulation of TBEV in nature is mediated by the non-viraemic transmission, between infected and. uninfected ticks co-feeding on the same hosts and. it was shown that transmission rate of «Hypr» strain (EU subtype) is much higher than rate of «Vasilchenko» strain (SIB subtype) - 60 and 5 % respectively. To reveal the viral determinants of transmission efficacy, we constructed the series of recombinant viruses with gradually exchanged genes coding structural (str) and. non-structural (ns) viral proteins. The recombinant virus Hypr[str]Vs[ns] achieved the rate of non-viraemic transmission of 70 %. The introduction of separate structural genes of Hypr into Vs infectious clone has enhanced the transmission efficacy as well, though not to such extent as entire structural region but up to 33 % only. Thus, it was shown that efficacy of non-viraemic transmission of TBEV depends from properties of viral structural proteins mainly.
format	article
author	M. A. Khasnatinov S. Havlikova A. Tuplin M. Kazimirova N. Goonavardane M. Slovak B. Klempa I. M. Jones M. Labuda E. A. Gould T. S. Gritsun
author_facet	M. A. Khasnatinov S. Havlikova A. Tuplin M. Kazimirova N. Goonavardane M. Slovak B. Klempa I. M. Jones M. Labuda E. A. Gould T. S. Gritsun
author_sort	M. A. Khasnatinov
title	THE ROLE OF THE STRUCTURAL PROTEINS IN THE NON-VIRAEMIC TRANSMISSION OF TICK-BORNE ENCEPHALITIS VIRUS
title_short	THE ROLE OF THE STRUCTURAL PROTEINS IN THE NON-VIRAEMIC TRANSMISSION OF TICK-BORNE ENCEPHALITIS VIRUS
title_full	THE ROLE OF THE STRUCTURAL PROTEINS IN THE NON-VIRAEMIC TRANSMISSION OF TICK-BORNE ENCEPHALITIS VIRUS
title_fullStr	THE ROLE OF THE STRUCTURAL PROTEINS IN THE NON-VIRAEMIC TRANSMISSION OF TICK-BORNE ENCEPHALITIS VIRUS
title_full_unstemmed	THE ROLE OF THE STRUCTURAL PROTEINS IN THE NON-VIRAEMIC TRANSMISSION OF TICK-BORNE ENCEPHALITIS VIRUS
title_sort	role of the structural proteins in the non-viraemic transmission of tick-borne encephalitis virus
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/a624e7cd27e14f93924e1f034a27fc10
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THE ROLE OF THE STRUCTURAL PROTEINS IN THE NON-VIRAEMIC TRANSMISSION OF TICK-BORNE ENCEPHALITIS VIRUS

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