Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation

Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation

Axon-glial communication is important for myelination. Here the authors show that during postnatal development in rats, a subpopulation of pre-myelinating oligodendrocytes in the auditory brainstem receive excitatory inputs and can generate Nav 1.2-driven action potentials, and that such process pro...

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Autores principales: Emmanuelle Berret, Tara Barron, Jie Xu, Emily Debner, Eun Jung Kim, Jun Hee Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a6255f710e5943b09ba26e809b38633c
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spelling oai:doaj.org-article:a6255f710e5943b09ba26e809b38633c2021-12-02T14:42:46ZOligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation10.1038/s41467-017-00688-02041-1723https://doaj.org/article/a6255f710e5943b09ba26e809b38633c2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00688-0https://doaj.org/toc/2041-1723Axon-glial communication is important for myelination. Here the authors show that during postnatal development in rats, a subpopulation of pre-myelinating oligodendrocytes in the auditory brainstem receive excitatory inputs and can generate Nav 1.2-driven action potentials, and that such process promotes myelination.Emmanuelle BerretTara BarronJie XuEmily DebnerEun Jung KimJun Hee KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Emmanuelle Berret
Tara Barron
Jie Xu
Emily Debner
Eun Jung Kim
Jun Hee Kim
Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation
description Axon-glial communication is important for myelination. Here the authors show that during postnatal development in rats, a subpopulation of pre-myelinating oligodendrocytes in the auditory brainstem receive excitatory inputs and can generate Nav 1.2-driven action potentials, and that such process promotes myelination.
format article
author Emmanuelle Berret
Tara Barron
Jie Xu
Emily Debner
Eun Jung Kim
Jun Hee Kim
author_facet Emmanuelle Berret
Tara Barron
Jie Xu
Emily Debner
Eun Jung Kim
Jun Hee Kim
author_sort Emmanuelle Berret
title Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation
title_short Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation
title_full Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation
title_fullStr Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation
title_full_unstemmed Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation
title_sort oligodendroglial excitability mediated by glutamatergic inputs and nav1.2 activation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a6255f710e5943b09ba26e809b38633c
work_keys_str_mv AT emmanuelleberret oligodendroglialexcitabilitymediatedbyglutamatergicinputsandnav12activation
AT tarabarron oligodendroglialexcitabilitymediatedbyglutamatergicinputsandnav12activation
AT jiexu oligodendroglialexcitabilitymediatedbyglutamatergicinputsandnav12activation
AT emilydebner oligodendroglialexcitabilitymediatedbyglutamatergicinputsandnav12activation
AT eunjungkim oligodendroglialexcitabilitymediatedbyglutamatergicinputsandnav12activation
AT junheekim oligodendroglialexcitabilitymediatedbyglutamatergicinputsandnav12activation
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